Vice-Reitoria de Pesquisa e Pós-Gradução, Universidade de Fortaleza, Av. Washington Soares 1321, Edson Queiroz, 60811-905, Fortaleza-CE, Brasil.
Indian J Pharmacol. 2011 Apr;43(2):180-2. doi: 10.4103/0253-7613.77359.
In this work, we report the antibacterial and modulatory activity of Lantana montevidensis Briq.
The antibacterial activities of leaf (LELm) and root (RELm) extracts alone or in association with aminoglycosides were determined by a microdilution test. Multiresistant strains of Escherichia coli (Ec 27) and Staphylococcus aureus (Sa 358) were used.
The results show the inhibitory activity of LELm against E. coli (minimal inhibitory concentration [MIC] 16 μg/mL) and S. aureus (MIC 128 μg/mL). The synergistic effect of the extracts and aminoglycosides was verified too. The maximum effects were obtained with RELm with gentamicin against E. coli with MIC reduction (312 to 2 μL).
The data from this study are indicative of the activity antibacterial of extracts of L. montevidensis and its potential in modifying the resistance of aminoglycosides.
本研究报告了马缨丹的抗菌和调节活性。
通过微量稀释试验测定了叶片（LELm）和根（RELm）提取物单独或与氨基糖苷类药物联合使用的抗菌活性。使用多药耐药大肠杆菌（Ec 27）和金黄色葡萄球菌（Sa 358）株。
结果表明，LELm 对大肠杆菌（最小抑菌浓度 [MIC] 16 μg/mL）和金黄色葡萄球菌（MIC 128 μg/mL）具有抑制活性。还验证了提取物和氨基糖苷类药物的协同作用。用 RELm 与庆大霉素对大肠杆菌的 MIC 降低（312 至 2 μL）获得最大效果。
本研究的数据表明，马缨丹提取物具有抗菌活性，并有潜力修饰氨基糖苷类药物的耐药性。
