2'-氟-2'-脱氧胞苷抑制博尔纳病病毒的复制和传播。
2'-fluoro-2'-deoxycytidine inhibits Borna disease virus replication and spread.
作者信息
Bajramovic Jeffrey J, Volmer Romain, Syan Sylvie, Pochet Sylvie, Gonzalez-Dunia Daniel
机构信息
Unité des Virus Lents, CNRS URA 1930, Institut Pasteur, Paris, France.
出版信息
Antimicrob Agents Chemother. 2004 Apr;48(4):1422-5. doi: 10.1128/AAC.48.4.1422-1425.2004.
Abstract
Borna disease virus (BDV) causes neurological diseases in a variety of warm-blooded animal species, possibly including humans. To date, there is no effective treatment against BDV infection. Recently, we reported on the antiviral activity of 1-beta-D-arabinofuranosylcytosine (Ara-C). However, Ara-C's cytotoxic side effects are a major obstacle for its therapeutic use. Herein, we demonstrate that the nucleoside analog 2'-fluoro-2'-deoxycytidine (2'-FdC) exhibits potent antiviral activity against BDV. Importantly, 2'-FdC-associated cytotoxicity is negligible, indicating 2'-FdC as an excellent candidate for the development of antiviral therapy against BDV.
摘要
博尔纳病病毒（BDV）可在多种温血动物物种中引发神经疾病，人类可能也包括在内。迄今为止，尚无针对BDV感染的有效治疗方法。最近，我们报道了1-β-D-阿拉伯呋喃糖基胞嘧啶（Ara-C）的抗病毒活性。然而，Ara-C的细胞毒性副作用是其治疗应用的主要障碍。在此，我们证明核苷类似物2'-氟-2'-脱氧胞苷（2'-FdC）对BDV具有强大的抗病毒活性。重要的是，2'-FdC相关的细胞毒性可忽略不计，这表明2'-FdC是开发抗BDV抗病毒疗法的极佳候选药物。
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