利巴韦林治疗的博尔纳病毒感染大鼠的神经保护作用及小胶质细胞增殖减少
Neuroprotection and reduced proliferation of microglia in ribavirin-treated bornavirus-infected rats.
作者信息
Solbrig Marylou V, Schlaberg Robert, Briese Thomas, Horscroft Nigel, Lipkin W Ian
机构信息
Emerging Diseases Laboratory, University of California-Irvine, Irvine, CA, USA.
出版信息
Antimicrob Agents Chemother. 2002 Jul;46(7):2287-91. doi: 10.1128/AAC.46.7.2287-2291.2002.
Abstract
In a rat model of Borna disease, intracerebral ribavirin caused clinical improvement without changes in virus titer or nucleic acid. Levels of microglia and infiltrating CD4 and CD8 cells were decreased, despite increases in mRNAs encoding interleukin-1beta (IL-1beta), IL-10, and gamma interferon in the brain. Intracerebral ribavirin may reduce morbidity through effects on microglia cell proliferation.
摘要
在博尔纳病大鼠模型中，脑内注射利巴韦林可使临床症状改善，而病毒滴度和核酸水平无变化。尽管脑中编码白细胞介素-1β（IL-1β）、IL-10和γ干扰素的mRNA有所增加，但小胶质细胞以及浸润的CD4和CD8细胞水平却降低了。脑内注射利巴韦林可能通过影响小胶质细胞增殖来降低发病率。
相似文献
1
Neuroprotection and reduced proliferation of microglia in ribavirin-treated bornavirus-infected rats.
Antimicrob Agents Chemother. 2002 Jul;46(7):2287-91. doi: 10.1128/AAC.46.7.2287-2291.2002.
2
Cytokine expression in the rat central nervous system following perinatal Borna disease virus infection.
J Neuroimmunol. 1999 Apr 1;96(1):29-45. doi: 10.1016/s0165-5728(98)00272-0.
3
Induction of degenerative brain lesions after adoptive transfer of brain lymphocytes from Borna disease virus-infected rats: presence of CD8+ T cells and perforin mRNA.
J Virol. 1997 Mar;71(3):2400-7. doi: 10.1128/JVI.71.3.2400-2407.1997.
4
Evolution of the immune response in the central nervous system following infection with Borna disease virus.
J Neuroimmunol. 1998 Oct 1;90(2):137-42. doi: 10.1016/s0165-5728(98)00076-9.
5
Kinetics of virus spread and changes in levels of several cytokine mRNAs in the brain after intranasal infection of rats with Borna disease virus.
J Virol. 1992 Feb;66(2):992-8. doi: 10.1128/JVI.66.2.992-998.1992.
6
Prevention of virus persistence and protection against immunopathology after Borna disease virus infection of the brain by a novel Orf virus recombinant.
J Virol. 2005 Jan;79(1):314-25. doi: 10.1128/JVI.79.1.314-325.2005.
7
Ribavirin inhibits Borna disease virus proliferation and fatal neurological diseases in neonatally infected gerbils.
Antiviral Res. 2008 Dec;80(3):380-4. doi: 10.1016/j.antiviral.2008.08.001. Epub 2008 Sep 7.
8
Direct evidence for immunomodulatory properties of ribavirin on T-cell reactivity to hepatitis C virus.
Antiviral Res. 2007 Jul;75(1):36-42. doi: 10.1016/j.antiviral.2006.11.008. Epub 2006 Dec 13.
9
The central nervous system inflammatory response to neurotropic virus infection is peroxynitrite dependent.
J Immunol. 2001 Sep 15;167(6):3470-7. doi: 10.4049/jimmunol.167.6.3470.
引用本文的文献
1
Ribavirin Treatment for Severe Schizophrenia with Anti-Borna Disease Virus 1 Antibodies 30 Years after Onset.
Case Rep Psychiatry. 2023 Feb 27;2023:4899364. doi: 10.1155/2023/4899364. eCollection 2023.
2
First detected geographical cluster of BoDV-1 encephalitis from same small village in two children: therapeutic considerations and epidemiological implications.
Infection. 2023 Oct;51(5):1383-1398. doi: 10.1007/s15010-023-01998-w. Epub 2023 Feb 23.
3
Avian Bornavirus Research-A Comprehensive Review.
Viruses. 2022 Jul 11;14(7):1513. doi: 10.3390/v14071513.
4
Healthcare-associated exposure to Borna disease virus 1 (BoDV-1).
J Occup Med Toxicol. 2022 Jun 9;17(1):13. doi: 10.1186/s12995-022-00353-3.
5
Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder.
Curr Pharm Des. 2020;26(4):466-484. doi: 10.2174/1381612826666200115094642.
6
Occupation-Associated Fatal Limbic Encephalitis Caused by Variegated Squirrel Bornavirus 1, Germany, 2013.
Emerg Infect Dis. 2018 Jun;24(6):978-987. doi: 10.3201/eid2406.172027.
7
A synthetic cannabinoid agonist promotes oligodendrogliogenesis during viral encephalitis in rats.
Exp Neurol. 2010 Nov;226(1):231-41. doi: 10.1016/j.expneurol.2010.09.003. Epub 2010 Sep 9.
8
Cannabinoid rescue of striatal progenitor cells in chronic Borna disease viral encephalitis in rats.
J Neurovirol. 2008 May;14(3):252-60. doi: 10.1080/13550280802074521.
9
Mechanism of the antiviral action of 1-beta-D-arabinofuranosylcytosine on Borna disease virus.
J Virol. 2005 Apr;79(7):4514-8. doi: 10.1128/JVI.79.7.4514-4518.2005.
10
2'-fluoro-2'-deoxycytidine inhibits Borna disease virus replication and spread.
Antimicrob Agents Chemother. 2004 Apr;48(4):1422-5. doi: 10.1128/AAC.48.4.1422-1425.2004.
本文引用的文献
1
Word recognition memory before and after successful treatment of depression.
Pharmacopsychiatry. 2000 Nov;33(6):221-8. doi: 10.1055/s-2000-8358.
2
The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen.
Nat Med. 2000 Dec;6(12):1375-9. doi: 10.1038/82191.
3
Borna disease in a free-ranging lynx (Lynx lynx).
J Clin Microbiol. 2000 Aug;38(8):3087-91. doi: 10.1128/JCM.38.8.3087-3091.2000.
4
Amantadine revisited: an open trial of amantadinesulfate treatment in chronically depressed patients with Borna disease virus infection.
Pharmacopsychiatry. 1999 Jul;32(4):142-7. doi: 10.1055/s-2007-979220.
5
Inhibition of Borna disease virus replication by ribavirin.
J Virol. 1999 Sep;73(9):7903-6. doi: 10.1128/JVI.73.9.7903-7906.1999.
6
Ribavirin polarizes human T cell responses towards a Type 1 cytokine profile.
J Hepatol. 1999 Mar;30(3):376-82. doi: 10.1016/s0168-8278(99)80093-2.
7
Effect of immune priming on Borna disease.
J Virol. 1999 Mar;73(3):2541-6. doi: 10.1128/JVI.73.3.2541-2546.1999.
8
Inhibition of Borna disease virus replication by ribavirin in persistently infected cells.
Arch Virol. 1998;143(10):2039-44. doi: 10.1007/s007050050440.
9
Resistance of naive mice to murine hepatitis virus strain 3 requires development of a Th1, but not a Th2, response, whereas pre-existing antibody partially protects against primary infection.
Adv Exp Med Biol. 1998;440:415-23. doi: 10.1007/978-1-4615-5331-1_52.
10
The antiviral compound ribavirin modulates the T helper (Th) 1/Th2 subset balance in hepatitis B and C virus-specific immune responses.
J Gen Virol. 1998 Oct;79 ( Pt 10):2381-91. doi: 10.1099/0022-1317-79-10-2381.
Zotero 插件