利巴韦林治疗的博尔纳病毒感染大鼠的神经保护作用及小胶质细胞增殖减少
Neuroprotection and reduced proliferation of microglia in ribavirin-treated bornavirus-infected rats.
作者信息
Solbrig Marylou V, Schlaberg Robert, Briese Thomas, Horscroft Nigel, Lipkin W Ian
机构信息
Emerging Diseases Laboratory, University of California-Irvine, Irvine, CA, USA.
出版信息
Antimicrob Agents Chemother. 2002 Jul;46(7):2287-91. doi: 10.1128/AAC.46.7.2287-2291.2002.
Abstract
In a rat model of Borna disease, intracerebral ribavirin caused clinical improvement without changes in virus titer or nucleic acid. Levels of microglia and infiltrating CD4 and CD8 cells were decreased, despite increases in mRNAs encoding interleukin-1beta (IL-1beta), IL-10, and gamma interferon in the brain. Intracerebral ribavirin may reduce morbidity through effects on microglia cell proliferation.
摘要
在博尔纳病大鼠模型中，脑内注射利巴韦林可使临床症状改善，而病毒滴度和核酸水平无变化。尽管脑中编码白细胞介素-1β（IL-1β）、IL-10和γ干扰素的mRNA有所增加，但小胶质细胞以及浸润的CD4和CD8细胞水平却降低了。脑内注射利巴韦林可能通过影响小胶质细胞增殖来降低发病率。
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