Antimalarial and antileishmanial activities of aroyl-pyrrolyl-hydroxyamides, a new class of histone deacetylase inhibitors.
作者信息
Mai Antonello, Cerbara Ilaria, Valente Sergio, Massa Silvio, Walker Larry A, Tekwani Babu L
出版信息
Antimicrob Agents Chemother. 2004 Apr;48(4):1435-6. doi: 10.1128/AAC.48.4.1435-1436.2004.
Abstract
摘要
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Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation.3-(4-苯甲酰基-1-甲基-1H-2-吡咯基)-N-羟基-2-丙烯酰胺的结合模式分析：一种新型合成组蛋白去乙酰化酶抑制剂，可诱导组蛋白高度乙酰化、生长抑制和终末细胞分化。
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Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents.组蛋白去乙酰化酶抑制剂与哺乳动物肿瘤细胞分化剂的抗疟作用
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