α/β干扰素与γ干扰素在抵御1型单纯疱疹病毒过程中与B细胞、T细胞和自然杀伤细胞之间的相互作用。
Interplay between alpha/beta and gamma interferons with B, T, and natural killer cells in the defense against herpes simplex virus type 1.
作者信息
Vollstedt Sabine, Arnold Susi, Schwerdel Cornelia, Franchini Marco, Alber Gottfried, Di Santo James P, Ackermann Mathias, Suter Mark
机构信息
Institute of Virology, University of Zurich, Zurich, Switzerland.
出版信息
J Virol. 2004 Apr;78(8):3846-50. doi: 10.1128/jvi.78.8.3846-3850.2004.
Abstract
The essential components of the immune system that control primary and chronic infection with herpes simplex virus type 1 (HSV-1) in mice were investigated. Infection within the first few days can be controlled by alpha/beta interferon (IFN-alpha/beta) alone without significant contribution of B, T, or NK cells. IFN-alpha/beta and IFN-gamma cooperate in the elimination of virus in the absence of these lymphocytes. In contrast, B, T, or NK cells appear to be required to control persistent infection with HSV-1. These results suggest that distinct and essential immune elements are recruited in a time-dependent fashion to control acute and persistent HSV-1 infection.
摘要
对小鼠中控制单纯疱疹病毒1型（HSV-1）原发性和慢性感染的免疫系统基本组成部分进行了研究。在最初几天内的感染可仅由α/β干扰素（IFN-α/β）控制，而B细胞、T细胞或自然杀伤（NK）细胞无显著作用。在缺乏这些淋巴细胞的情况下，IFN-α/β和IFN-γ协同作用以清除病毒。相比之下，控制HSV-1的持续性感染似乎需要B细胞、T细胞或NK细胞。这些结果表明，不同且必需的免疫成分会以时间依赖的方式被募集，以控制HSV-1的急性和持续性感染。
相似文献
1
Interplay between alpha/beta and gamma interferons with B, T, and natural killer cells in the defense against herpes simplex virus type 1.α/β干扰素与γ干扰素在抵御1型单纯疱疹病毒过程中与B细胞、T细胞和自然杀伤细胞之间的相互作用。
J Virol. 2004 Apr;78(8):3846-50. doi: 10.1128/jvi.78.8.3846-3850.2004.
2
Interleukin-12- and gamma interferon-dependent innate immunity are essential and sufficient for long-term survival of passively immunized mice infected with herpes simplex virus type 1.白细胞介素-12和γ干扰素依赖性天然免疫对于被动免疫的感染1型单纯疱疹病毒小鼠的长期存活至关重要且足够。
J Virol. 2001 Oct;75(20):9596-600. doi: 10.1128/JVI.75.20.9596-9600.2001.
3
Immune- and Nonimmune-Compartment-Specific Interferon Responses Are Critical Determinants of Herpes Simplex Virus-Induced Generalized Infections and Acute Liver Failure.免疫和非免疫区室特异性干扰素反应是单纯疱疹病毒诱导的全身性感染和急性肝衰竭的关键决定因素。
J Virol. 2016 Nov 14;90(23):10789-10799. doi: 10.1128/JVI.01473-16. Print 2016 Dec 1.
4
Innate and acquired immunity to herpes simplex virus type 1.对1型单纯疱疹病毒的先天性免疫和获得性免疫。
Virology. 1997 Sep 29;236(2):328-37. doi: 10.1006/viro.1997.8738.
5
Establishment of latent herpes simplex virus type 1 infection in resistant, sensitive, and immunodeficient mouse strains.在抗性、敏感和免疫缺陷小鼠品系中建立1型单纯疱疹病毒潜伏感染。
Virology. 2000 Mar 1;268(1):17-28. doi: 10.1006/viro.1999.0158.
6
Herpes simplex virus type 2 virion host shutoff protein regulates alpha/beta interferon but not adaptive immune responses during primary infection in vivo.2型单纯疱疹病毒病毒体宿主关闭蛋白在体内原发性感染期间调节α/β干扰素，但不调节适应性免疫反应。
J Virol. 2003 Sep;77(17):9337-45. doi: 10.1128/jvi.77.17.9337-9345.2003.
7
Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1.重新评估自然杀伤细胞在对1型单纯疱疹病毒先天抵抗力中的作用。
Virol J. 2005 Jul 17;2:56. doi: 10.1186/1743-422X-2-56.
8
Dendritic cells, macrophages, NK and CD8 T lymphocytes play pivotal roles in controlling HSV-1 in the trigeminal ganglia by producing IL1-beta, iNOS and granzyme B.树突状细胞、巨噬细胞、自然杀伤细胞和CD8 T淋巴细胞通过产生白细胞介素-1β、诱导型一氧化氮合酶和颗粒酶B，在控制三叉神经节中的单纯疱疹病毒1型方面发挥关键作用。
Virol J. 2017 Feb 21;14(1):37. doi: 10.1186/s12985-017-0692-x.
9
Dendritic cells from mice neonatally vaccinated with modified vaccinia virus Ankara transfer resistance against herpes simplex virus type I to naive one-week-old mice.用安卡拉痘苗病毒对新生小鼠进行疫苗接种后，其树突状细胞可将针对I型单纯疱疹病毒的抗性传递给一周龄的未接触过该病毒的小鼠。
J Immunol. 2004 May 15;172(10):6304-12. doi: 10.4049/jimmunol.172.10.6304.
10
引用本文的文献
1
The immunogenetic basis of severe herpes simplex infections in neonates and children: a review.新生儿和儿童严重单纯疱疹感染的免疫遗传学基础：综述
Pediatr Res. 2025 Jan 18. doi: 10.1038/s41390-025-03830-7.
2
Infectious origin of Alzheimer's disease: Amyloid beta as a component of brain antimicrobial immunity.阿尔茨海默病的传染性起源：β-淀粉样蛋白作为脑抗菌免疫的一个组成部分。
PLoS Pathog. 2022 Nov 17;18(11):e1010929. doi: 10.1371/journal.ppat.1010929. eCollection 2022 Nov.
3
Herpes Simplex Virus 1 Infection of Neuronal and Non-Neuronal Cells Elicits Specific Innate Immune Responses and Immune Evasion Mechanisms.单纯疱疹病毒 1 感染神经元和非神经元细胞会引发特定的先天免疫反应和免疫逃避机制。
Front Immunol. 2021 May 31;12:644664. doi: 10.3389/fimmu.2021.644664. eCollection 2021.
4
Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES).发热感染相关癫痫综合征（FIRES）中 Toll 样受体反应减弱。
Biomed J. 2020 Jun;43(3):293-304. doi: 10.1016/j.bj.2020.05.007. Epub 2020 May 29.
5
Host Intrinsic and Innate Intracellular Immunity During Herpes Simplex Virus Type 1 (HSV-1) Infection.单纯疱疹病毒1型（HSV-1）感染期间的宿主固有和先天性细胞内免疫
Front Microbiol. 2019 Nov 8;10:2611. doi: 10.3389/fmicb.2019.02611. eCollection 2019.
6
Synergistic effect of ribavirin and vaccine for protection during early infection stage of foot-and-mouth disease.利巴韦林与疫苗在口蹄疫早期感染阶段协同发挥保护作用。
J Vet Sci. 2018 Nov 30;19(6):788-797. doi: 10.4142/jvs.2018.19.6.788.
7
Decreased absolute numbers of CD3 T cells and CD8 T cells during aging in herpes zoster patients.在带状疱疹患者中，衰老过程中 CD3 T 细胞和 CD8 T 细胞的绝对值减少。
Sci Rep. 2017 Nov 8;7(1):15039. doi: 10.1038/s41598-017-15390-w.
8
Corticosterone, inflammation, immune status and telomere length in frigatebird nestlings facing a severe herpesvirus infection.面临严重疱疹病毒感染的军舰鸟雏鸟体内的皮质酮、炎症、免疫状态和端粒长度
Conserv Physiol. 2017 Jan 4;5(1):cow073. doi: 10.1093/conphys/cow073. eCollection 2017.
9
Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment.单纯疱疹病毒1型的潜伏期进入由其基因组与核环境的相互作用决定。
PLoS Pathog. 2016 Sep 12;12(9):e1005834. doi: 10.1371/journal.ppat.1005834. eCollection 2016 Sep.
10
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.潜伏期间，驻留T细胞无法控制脑室内区域的单纯疱疹病毒1型活性。
J Immunol. 2016 Aug 15;197(4):1262-75. doi: 10.4049/jimmunol.1600207. Epub 2016 Jun 29.
本文引用的文献
1
The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses.白细胞介素-12异二聚体细胞因子家族：T细胞反应调节中的新成员。
Immunity. 2003 Nov;19(5):641-4. doi: 10.1016/s1074-7613(03)00296-6.
2
Alpha/Beta interferon and gamma interferon synergize to inhibit the replication of herpes simplex virus type 1.α/β干扰素和γ干扰素协同作用以抑制1型单纯疱疹病毒的复制。
J Virol. 2002 Nov;76(22):11541-50. doi: 10.1128/jvi.76.22.11541-11550.2002.
3
Viruses and interferon: a fight for supremacy.病毒与干扰素：一场争夺主导权的斗争。
Nat Rev Immunol. 2002 Sep;2(9):675-87. doi: 10.1038/nri888.
4
Rapid cytotoxic T lymphocyte activation occurs in the draining lymph nodes after cutaneous herpes simplex virus infection as a result of early antigen presentation and not the presence of virus.皮肤单纯疱疹病毒感染后，由于早期抗原呈递而非病毒的存在，引流淋巴结中会迅速发生细胞毒性T淋巴细胞活化。
J Exp Med. 2002 Mar 4;195(5):651-6. doi: 10.1084/jem.20012023.
5
Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice.小鼠中单纯疱疹病毒1型潜伏状态的自发分子再激活
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):978-83. doi: 10.1073/pnas.022301899. Epub 2002 Jan 2.
6
A protective and agonistic function of IL-12p40 in mycobacterial infection.白细胞介素-12p40在分枝杆菌感染中的保护和激动功能。
J Immunol. 2001 Dec 15;167(12):6957-66. doi: 10.4049/jimmunol.167.12.6957.
7
Gamma interferon can prevent herpes simplex virus type 1 reactivation from latency in sensory neurons.γ干扰素可预防单纯疱疹病毒1型在感觉神经元中从潜伏状态重新激活。
J Virol. 2001 Nov;75(22):11178-84. doi: 10.1128/JVI.75.22.11178-11184.2001.
8
Interleukin-12- and gamma interferon-dependent innate immunity are essential and sufficient for long-term survival of passively immunized mice infected with herpes simplex virus type 1.白细胞介素-12和γ干扰素依赖性天然免疫对于被动免疫的感染1型单纯疱疹病毒小鼠的长期存活至关重要且足够。
J Virol. 2001 Oct;75(20):9596-600. doi: 10.1128/JVI.75.20.9596-9600.2001.
9
Inducible IL-2 production by dendritic cells revealed by global gene expression analysis.通过全基因表达分析揭示树突状细胞诱导性白细胞介素-2的产生。
Nat Immunol. 2001 Sep;2(9):882-8. doi: 10.1038/ni0901-882.
10
Identification of committed NK cell progenitors in adult murine bone marrow.成年小鼠骨髓中定向自然杀伤细胞祖细胞的鉴定。
Eur J Immunol. 2001 Jun;31(6):1900-9. doi: 10.1002/1521-4141(200106)31:6<1900::aid-immu1900>3.0.co;2-m.
Zotero 插件