Choi Joo-Hyung, Jeong Kwiwan, Kim Su-Mi, Ko Mi-Kyeong, You Su-Hwa, Lyoo Young S, Kim Byounghan, Ku Jin-Mo, Park Jong-Hyeon
Animal and Plant Quarantine Agency, Gimcheon 39660, Korea.
Bio-Center, Gyeonggi Business & Science Accelerator, Suwon 16229, Korea.
J Vet Sci. 2018 Nov 30;19(6):788-797. doi: 10.4142/jvs.2018.19.6.788.
In many countries, vaccines are used for the prevention of foot-and-mouth disease (FMD). However, because there is no protection against FMD immediately after vaccination, research and development on antiviral agents is being conducted to induce protection until immunological competence is produced. This study tested whether well-known chemicals used as RNA virus treatment agents had inhibitory effects on FMD viruses (FMDVs) and demonstrated that ribavirin showed antiviral effects against FMDV . In addition, it was observed that combining the administration of the antiviral agents orally and complementary therapy with vaccines synergistically enhanced antiviral activity and preserved the survival rate and body weight in the experimental animals. Antiviral agents mixed with an adjuvant were inoculated intramuscularly along with the vaccines, thereby inhibiting virus replication after injection and verifying that it was possible to induce early protection against viral infection prior to immunity being achieved through the vaccine. Finally, pigs treated with antiviral agents and vaccines showed no clinical signs and had low virus excretion. Based on these results, it is expected that this combined approach could be a therapeutic and preventive treatment for early protection against FMD.
在许多国家，疫苗被用于预防口蹄疫（FMD）。然而，由于接种疫苗后不能立即对口蹄疫产生保护作用，因此正在开展抗病毒药物的研发工作，以在产生免疫能力之前诱导保护作用。本研究测试了用作RNA病毒治疗剂的知名化学物质是否对口蹄疫病毒（FMDV）具有抑制作用，并证明利巴韦林显示出针对FMDV的抗病毒作用。此外，观察到口服抗病毒药物与疫苗的辅助疗法相结合可协同增强抗病毒活性，并在实验动物中维持存活率和体重。将与佐剂混合的抗病毒药物与疫苗一起进行肌肉注射，从而在注射后抑制病毒复制，并证实有可能在通过疫苗实现免疫之前诱导对病毒感染的早期保护。最后，用抗病毒药物和疫苗治疗的猪没有出现临床症状，并且病毒排泄量很低。基于这些结果，预计这种联合方法可能成为预防口蹄疫早期保护的治疗和预防手段。
