Pouniotis D S, Proudfoot O, Minigo G, Hanley J L, Plebanski M
Vaccine Development and Infectious Diseases Unit, The Austin Research Institute, Austin Campus, Heidelberg, Victoria 3084, Australia.
J Postgrad Med. 2004 Jan-Mar;50(1):30-4.
The interaction between the malaria parasite and the human host involves a number of interactions that result in the parasite evading the human immune system. Since the stages of the malaria lifecycle are complex, this allows the use of various immune evasion strategies by the malaria parasite and has major implications in the development of a vaccine for malaria endemic areas. The present review highlights key host:parasite interactions. Plasmodia puts selection pressure on human gene frequencies, and studies into host genetic factors such as the Duffy blood group and sickle cell anaemia offer insight into the host- parasite relationship. In addition, parasite interactions with the different effector arms of the immune system can result in altered peptide ligand (APL) antagonism which alters the immune response from a pro- to an anti-inflammatory T cell response. Recent insights into the interaction between professional antigen presenting cells, dendritic cells (DCs), and malaria parasites is discussed in detail.
疟原虫与人类宿主之间的相互作用涉及多种相互作用，这些相互作用导致疟原虫逃避人类免疫系统。由于疟疾生命周期的各个阶段很复杂，这使得疟原虫能够采用各种免疫逃避策略，并且对疟疾流行地区疫苗的研发具有重大影响。本综述重点介绍了关键的宿主与寄生虫相互作用。疟原虫对人类基因频率施加选择压力，对诸如达菲血型和镰状细胞贫血等宿主遗传因素的研究有助于深入了解宿主与寄生虫的关系。此外，寄生虫与免疫系统不同效应臂的相互作用可导致改变肽配体（APL）拮抗作用，从而将免疫反应从促炎性T细胞反应转变为抗炎性T细胞反应。本文详细讨论了对专业抗原呈递细胞、树突状细胞（DC）与疟原虫之间相互作用的最新见解。
