Stevens Raymond C
Department of Molecular Biology and Chemistry at the Scripps Research Institute, La Jolla, California 92037, USA.
Nat Struct Mol Biol. 2004 Apr;11(4):293-5. doi: 10.1038/nsmb0404-293.
Two camps continue to evolve in the field of structural biology--a 'systems-oriented' camp, which studies proteins or complexes carefully one system at a time, and a 'discovery-oriented' one, which studies proteins of entire families, pathways or genomes. The end goals of both camps are the same: to decipher the atomic-resolution structures and mechanisms of biological macromolecules and understand them in the context of the living cell.
在结构生物学领域，两个阵营仍在不断发展——一个是“面向系统”的阵营，该阵营一次只仔细研究一个系统中的蛋白质或复合物；另一个是“面向发现”的阵营，该阵营研究整个家族、途径或基因组的蛋白质。两个阵营的最终目标是相同的：破译生物大分子的原子分辨率结构和机制，并在活细胞的背景下理解它们。
