Ryan L J, Sanders D J, Clark K B
Department of Psychology, Oregon State University, Corvallis 97331-5303.
Brain Res. 1992 Jun 26;583(1-2):253-61. doi: 10.1016/s0006-8993(10)80031-9.
Statistical analyses (autocorrelation and first-order interstimulus interval) were conducted on the spontaneous activity of over 420 subthalamic neurons recorded in 5 groups (control, large globus pallidus kainic acid lesion, partial globus pallidus kainic acid lesion, partial globus pallidus ibotenic acid lesion and neostriatal lesion) of anesthetized rats. Cross-correlation and peristimulus time histogram (to frontal motor cortex stimulation at 0.7 mA) analyses were conducted on pairs (n = 58) of subthalamic neurons recorded simultaneously on a single microelectrode. Lesion of the globus pallidus increased spontaneous firing rate as compared to controls and shifted the pattern of spontaneous activity from either a regular or irregular pattern to a markedly bursting pattern. Neostriatal lesion reduced firing rate and reduced the likelihood of highly regular firing. In control, neostriatal and partial lesioned animals, approximately 1 in 3 pairs of neurons showed correlated firing. The correlations were joint increased probabilities of firing over intervals of 200-400 ms, suggesting a shared excitatory input. No short-interval (less than 10 ms) correlations were seen. Large globus pallidus lesion increased the likelihood of correlated firing (12 of 16 pairs). In all groups of animals the peristimulus time histograms (PSTHs) to motor cortex stimulation were more similar than would be expected by chance and pairs of neurons showed the same increases in response following globus pallidus lesion. Thus adjacent neurons share common cortical inputs and responsiveness to those inputs. These changes indicate that the globus pallidus influences the spontaneous firing rate and pattern of subthalamic neurons as well as the degree of correlated firing of adjacent neurons.
对5组（对照组、大苍白球 kainic 酸损伤组、部分苍白球 kainic 酸损伤组、部分苍白球鹅膏蕈氨酸损伤组和新纹状体损伤组）麻醉大鼠记录的420多个丘脑底核神经元的自发活动进行了统计分析（自相关和一阶刺激间隔）。对在单个微电极上同时记录的丘脑底核神经元对（n = 58）进行了互相关和刺激时间直方图分析（对0.7 mA的额叶运动皮层刺激）。与对照组相比，苍白球损伤增加了自发放电率，并将自发活动模式从规则或不规则模式转变为明显的爆发模式。新纹状体损伤降低了放电率，并降低了高度规则放电的可能性。在对照组、新纹状体损伤组和部分损伤动物中，约三分之一的神经元对显示出相关放电。这些相关性是在200 - 400毫秒间隔内共同增加的放电概率，表明存在共享的兴奋性输入。未观察到短间隔（小于10毫秒）的相关性。大苍白球损伤增加了相关放电的可能性（16对中有12对）。在所有动物组中，对运动皮层刺激的刺激时间直方图（PSTHs）比偶然预期的更相似，并且神经元对在苍白球损伤后显示出相同的反应增加。因此，相邻神经元共享共同的皮层输入以及对这些输入的反应性。这些变化表明苍白球影响丘脑底核神经元的自发放电率和模式以及相邻神经元的相关放电程度。
