Hassani O K, Mouroux M, Féger J
Laboratoire de Pharmacologie, Faculté des Sciences Pharmaceutiques et Biologiques, Université R. Descartes, Paris, France.
Neuroscience. 1996 May;72(1):105-15. doi: 10.1016/0306-4522(95)00535-8.
Electrophysiological records of unit activity were used to compare the effects of excitotoxic pallidal lesions and 6-hydroxydopamine-induced damage to the midbrain dopaminergic neurons on the discharge rates and patterns of the subthalamic neurons. Removal of the pallidal input induced a slight, but statistically significant, increase (19.5%) in the discharge rate and no change in the firing pattern when compared to control animals. The rats with a dopaminergic lesion showed greater increase (105.7%) while the firing pattern activity of the subthalamic neurons became more irregular, with burst. These results indicate that the increased activity of the subthalamic neurons following a midbrain dopaminergic lesion cannot be due solely to inhibition-disinhibition involving the striato-pallido-subthalamic pathway and induced by the striatal dopaminergic depletion.
利用单位活动的电生理记录，比较兴奋性毒性苍白球损伤和6-羟基多巴胺诱导的中脑多巴胺能神经元损伤对丘脑底核神经元放电率和放电模式的影响。与对照动物相比，去除苍白球输入导致放电率轻微但具有统计学意义的增加（19.5%），且放电模式无变化。多巴胺能损伤的大鼠表现出更大的增加（105.7%），而丘脑底核神经元的放电模式活动变得更加不规则，并出现爆发。这些结果表明，中脑多巴胺能损伤后丘脑底核神经元活动的增加不能仅仅归因于纹状体-苍白球-丘脑底核通路的去抑制作用，该作用由纹状体多巴胺能耗竭诱导。
