Algan Ocal Pelin, Akşahin Arzu, Cetin Türkan, Yildirim I Safa
Social Security Ankara Education Hospital, 3rd Internal Medicine Clinic, Ankara, Turkey.
Turk J Gastroenterol. 2003 Dec;14(4):257-61.
BACKGROUND/AIMS: Cancer antigen 125 is a glycoprotein of 220 kDA molecular weight, that is released from coelomic epithelium during embryonic development. It has a low specificity, and high levels have been shown in many benign and malignant diseases. High correlation was detected between its level and ascites, especially in cirrhotic patients. In this study, we aimed to evaluate cancer antigen 125 levels in patients with ascites and determine the relationship between these levels and the amount of ascites.
Fifty-eight patients (25 men, 33 women, mean age 54.34 years) with ascites, hospitalized in our clinic, were included in the study. The patients with ovarian cancer were not included. For all patients, physical examination and abdominal USG were done and blood samples for routine screening and cancer antigen 125 were obtained and studied on the same day.
Mean cancer antigen 125 levels in all patients were higher than normal. The highest levels were detected in patients with massive ascites and cirrhosis. With regard to diagnosis, the levels of cancer antigen 125 between groups were insignificant. According to USG results, there was a weakly positive but important correlation between groups. Although no correlation was present between cancer antigen 125 and ALT levels, a weak but positive correlation was present with AST levels.
Our study showed that a correlation is present between cancer antigen 125 levels and the presence and amount of ascites. We also suggest that if cancer antigen 125 levels are above normal, the presence of ascites not detected by physical examination should be kept in mind.
背景/目的：癌抗原125是一种分子量为220 kDa的糖蛋白，在胚胎发育过程中由体腔上皮释放。其特异性较低，在许多良性和恶性疾病中均显示出高水平。已检测到其水平与腹水之间存在高度相关性，尤其是在肝硬化患者中。在本研究中，我们旨在评估腹水患者的癌抗原125水平，并确定这些水平与腹水量之间的关系。
纳入我院门诊收治的58例腹水患者（25例男性，33例女性，平均年龄54.34岁）。不包括卵巢癌患者。对所有患者进行体格检查和腹部超声检查，并于同一天采集血样进行常规筛查和癌抗原125检测。
所有患者的癌抗原125平均水平均高于正常。大量腹水和肝硬化患者的水平最高。关于诊断，各组之间癌抗原125水平无显著差异。根据超声检查结果，各组之间存在弱阳性但重要的相关性。虽然癌抗原125与谷丙转氨酶水平之间无相关性，但与谷草转氨酶水平存在弱但阳性的相关性。
我们的研究表明，癌抗原125水平与腹水的存在及量之间存在相关性。我们还建议，如果癌抗原125水平高于正常，应考虑存在体格检查未发现的腹水。
