Bérard Frédéric, Guillot Isabelle, Saad Nathalie, Nicolas Jean-François
Immunologie clinique et allergologie, CHU Lyon-Sud, Hospices civils de Lyon, 69495 Pierre-Bénite Cedex.
Rev Prat. 2004 Jan 15;54(1):28-34.
Recent advances in the treatment of psoriasis have led to improve understanding in the pathogenesis of the disease. Skin lesions are scaling erythematous plaques. Although initially considered as a disease of epidermal cells, it is now widely accepted that the epidermal abnormalities, which are characteristic of the disease, are secondary to the development of a skin inflammation. Psoriasis is an autoimmune disease due to the activation in the skin of antigen-specific T cells leading to release of cytokines that results in proliferation of keratinocytes. However, the autoantigen(s) is (are) yet unknown. Several new biological treatments have been developed, which target specific steps in the pathophysiology of the disease.
银屑病治疗方面的最新进展增进了人们对该疾病发病机制的理解。皮肤损害为鳞屑性红斑斑块。尽管最初被认为是一种表皮细胞疾病，但现在人们普遍认为，作为该疾病特征的表皮异常是皮肤炎症发展的继发表现。银屑病是一种自身免疫性疾病，因为皮肤中抗原特异性T细胞的激活会导致细胞因子释放，进而引起角质形成细胞增殖。然而，自身抗原仍不明确。已经开发了几种新的生物治疗方法，它们针对该疾病病理生理学中的特定环节。
