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Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein.

作者信息

Lai Z C, Rubin G M

机构信息

Howard Hughes Medical Institute, University of California, Berkeley 94720.

出版信息

Cell. 1992 Aug 21;70(4):609-20. doi: 10.1016/0092-8674(92)90430-k.

DOI:10.1016/0092-8674(92)90430-k
PMID:1505027
Abstract

Loss-of-function mutations in the yan gene result in the differentiation of supernumerary photoreceptors in the Drosophila eye. The yan gene encodes a protein with an ETS DNA-binding domain that accumulates in the nuclei of undifferentiated cells during the early stages of eye development. Our data suggest that yan functions as a cell-autonomous negative regulator of photoreceptor development; in the presumptive R7 and cone cells, yan appears to act antagonistically to the proneural signal mediated by sevenless and Ras1.

摘要

相似文献

1
Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein.
Cell. 1992 Aug 21;70(4):609-20. doi: 10.1016/0092-8674(92)90430-k.
2
Yan regulates Lozenge during Drosophila eye development.Yan在果蝇眼睛发育过程中调节菱形蛋白。
Dev Genes Evol. 2002 Jul;212(6):267-76. doi: 10.1007/s00427-002-0241-4. Epub 2002 Jun 13.
3
The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway.果蝇眼睛发育所需的两种Ets相关转录因子的活性受Ras/MAPK信号通路调控。
Cell. 1994 Jul 15;78(1):137-47. doi: 10.1016/0092-8674(94)90580-0.
4
JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye.JUN与ETS结构域蛋白Pointed协同作用，诱导果蝇眼睛中的感光细胞R7命运。
Cell. 1995 Dec 1;83(5):753-60. doi: 10.1016/0092-8674(95)90188-4.
5
pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor.Pokkuri是一种果蝇基因，编码一种E-26特异性（Ets）结构域蛋白，可防止R7光感受器过度产生。
Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6856-60. doi: 10.1073/pnas.89.15.6856.
6
Loss of tramtrack gene activity results in ectopic R7 cell formation, even in a sina mutant background.即使在sina突变体背景下，tramtrack基因活性的丧失也会导致异位R7细胞的形成。
Proc Natl Acad Sci U S A. 1996 May 14;93(10):5025-30. doi: 10.1073/pnas.93.10.5025.
7
tramtrack is a transcriptional repressor required for cell fate determination in the Drosophila eye.tramtrack是果蝇眼睛中细胞命运决定所需的一种转录抑制因子。
Genes Dev. 1993 Jun;7(6):1085-96. doi: 10.1101/gad.7.6.1085.
8
Repression of Drosophila photoreceptor cell fate through cooperative action of two transcriptional repressors Yan and Tramtrack.通过两种转录抑制因子Yan和Tramtrack的协同作用抑制果蝇光感受器细胞命运
Genetics. 1997 Nov;147(3):1131-7. doi: 10.1093/genetics/147.3.1131.
9
The yan gene is highly conserved in Drosophila and its expression suggests a complex role throughout development.yan基因在果蝇中高度保守，其表达表明在整个发育过程中发挥着复杂的作用。
Dev Genes Evol. 1999 Apr;209(4):207-17. doi: 10.1007/s004270050245.
10
Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway.Yan作为一种分化的通用抑制剂，并受到Ras1/MAPK途径激活的负调控。
Cell. 1995 Jun 16;81(6):857-66. doi: 10.1016/0092-8674(95)90006-3.

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