Gupta Sudhir, Bi Ruifen, Su Kevin, Yel Leman, Chiplunkar Sujata, Gollapudi Sastry
Division of Basic and Clinical Immunology, Medical Sciences C C-240, University of California, Irvine, CA 92697 4069, USA.
Exp Gerontol. 2004 Apr;39(4):545-50. doi: 10.1016/j.exger.2003.08.013.
Aging is associated with progressive decline in T cell functions and increased frequency of infections, autoimmune phenomenon, and cancer. Memory T cells rapidly acquire effector functions to kill infected and malignant cells and/or inhibit their replication. Recently, memory T cells have been further classified into central and effector memory T cells (and early and intermediate T cells by some investigators). In aging, memory T cells are accumulated; however, these subpopulations of memory and effector T cells have not been fully characterized and changes in central memory and effector memory T cells in aged humans have not been described. In this article, we have further defined naïve, central memory, effector memory, and effector CD8+ T cells in humans and their changes in aged humans.
衰老与T细胞功能的逐渐衰退以及感染、自身免疫现象和癌症发生率的增加相关。记忆T细胞迅速获得效应功能以杀死被感染和恶性细胞及/或抑制其复制。最近，记忆T细胞被进一步分为中枢记忆T细胞和效应记忆T细胞（一些研究者还划分出早期和中期T细胞）。在衰老过程中，记忆T细胞会累积；然而，这些记忆T细胞和效应T细胞亚群尚未得到充分表征，老年人体内中枢记忆T细胞和效应记忆T细胞的变化也未被描述。在本文中，我们进一步明确了人类体内的初始、中枢记忆、效应记忆和效应CD8+ T细胞及其在老年人中的变化。
