经前烦躁障碍与额叶α波不对称性变化
Premenstrual dysphoric disorder and changes in frontal alpha asymmetry.
作者信息
Baehr Elsa, Rosenfeld Peter, Miller Laura, Baehr Rufus
机构信息
Department of Psychiatry and Behavioral Sciences, Northwestern University Medical School, Chicago, IL 60611, NeuroQuest, Inc., 1603 Orrington Ave., Evanston, IL 60201, USA.
出版信息
Int J Psychophysiol. 2004 Apr;52(2):159-67. doi: 10.1016/j.ijpsycho.2003.06.002.
OBJECTIVE
Since the clinical picture of premenstrual dysphoric disorder (PMDD) in the Luteal phase of the menstrual cycle is characterized by extreme negative affect, we predicted and obtained a change in frontal cortical EEG alpha asymmetry, which has been shown to be an index of affect.
METHOD
We observed two monthly cycles for five women diagnosed as having PMDD and one monthly cycle for five non-PMDD control subjects.
RESULTS
Asymmetry percent scores for the five PMDD women, and for the five control subjects before and after the Luteal phase were typically within the normal non-depressed range, however the asymmetry scores for the PMDD group fell into the negative range during the Luteal period while the control subjects remained stable.
DISCUSSION
We predicted alpha asymmetry scores would be affected by the luteal phase in PMDD cases. This hypothesis was clearly confirmed.
目的
由于经前烦躁障碍（PMDD）在月经周期黄体期的临床表现以极端消极情绪为特征，我们预测并观察到额叶皮质脑电图α波不对称性发生变化，而这已被证明是情绪的一个指标。
方法
我们观察了5名被诊断患有PMDD的女性的两个月经周期，以及5名非PMDD对照受试者的一个月经周期。
结果
5名PMDD女性以及5名对照受试者在黄体期前后的不对称百分比分数通常在正常非抑郁范围内，然而，PMDD组在黄体期的不对称分数降至负值范围，而对照受试者则保持稳定。
讨论
我们预测α波不对称分数会在PMDD病例的黄体期受到影响。这一假设得到了明确证实。
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