Coles R R, Thompson A C, O'Donoghue G M
MRC Institute of Hearing Research, University Park, Nottingham, UK.
Clin Otolaryngol Allied Sci. 1992 Jun;17(3):240-2. doi: 10.1111/j.1365-2273.1992.tb01835.x.
Prolonged reduction or abolition of tinnitus has been reported in about two-thirds of patients treated with a single or weekly-repeated injection through the tympanic membrane of either dexamethasone or lignocaine. In a small-scale trial of these treatments, dexamethasone gave 6 patients little benefit but few side-effects. Lignocaine gave 5 patients no lasting benefit but violent vertigo for several hours. A. Axelsson (personal communication) had similar experience with 6 patients treated with intra-tympanic lignocaine. It is concluded that this form of treatment does not seem sufficiently effective to offset its low acceptability.
据报道,约三分之二接受地塞米松或利多卡因经鼓膜单次或每周重复注射治疗的患者,耳鸣症状得到了长期缓解或消失。在这些治疗方法的一项小规模试验中,地塞米松对6名患者几乎没有益处,但副作用很少。利多卡因对5名患者没有带来持久的益处,但会导致数小时的剧烈眩晕。A. 阿克塞尔松(个人交流)对6名接受鼓室内利多卡因治疗的患者也有类似的经验。得出的结论是,这种治疗方式似乎没有足够的效果来抵消其较低的可接受性。