Gilbertson Richard J
Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Lancet Oncol. 2004 Apr;5(4):209-18. doi: 10.1016/S1470-2045(04)01424-X.
Medulloblastoma is the most common malignant brain tumour that occurs during childhood. Multimodality treatment regimens have substantially improved survival in this disease; however, the tumour is incurable in about a third of patients with medulloblastoma, and current treatment has a detrimental effect on long-term survivors. Drugs that target cell-signalling pathways provide an alternative to conventional cytotoxic approaches to treatment of cancer. Several pathways have been implicated in medulloblastoma formation, and knowledge of these is now being used to develop new ways of treating children with medulloblastoma.
髓母细胞瘤是儿童期最常见的恶性脑肿瘤。多模态治疗方案已显著提高了这种疾病的生存率；然而，约三分之一的髓母细胞瘤患者的肿瘤仍无法治愈，且目前的治疗方法对长期存活者有不良影响。靶向细胞信号通路的药物为癌症治疗提供了一种替代传统细胞毒性方法的选择。有几种信号通路与髓母细胞瘤的形成有关，目前正利用对这些信号通路的了解来开发治疗髓母细胞瘤患儿的新方法。
