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3-[苯基(1,3-噻唑-2-基)氨基]丙酸及其衍生物的合成与生物活性。

Synthesis and biological activity of 3-[phenyl(1,3-thiazol-2-yl)-amino]propanoic acids and their derivatives.

机构信息

Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, LT-50254 Kaunas, Lithuania.

出版信息

Molecules. 2013 Dec 5;18(12):15000-18. doi: 10.3390/molecules181215000.

DOI:10.3390/molecules181215000
PMID:24317527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6269796/
Abstract

New N,N-disubstituted β-amino acids and their derivatives with thiazole, aromatic, and heterocyclic substituents were synthesized from N-phenyl-N-thiocarbamoyl-β-alanine by the Hantzsch method; derivatives with hydrazone fragments were also obtained. Some of the synthesized compounds exhibited discrete antimicrobial activity, and 3-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)(phenyl)amino]propanoic acid was found to promote rapeseed growth and to increase seed yield and oil content.

摘要

新型 N,N-二取代β-氨基酸及其噻唑、芳基和杂环取代衍生物是由 N-苯甲酰基-N-硫代氨基丁酸通过 Hantzsch 法合成的；还得到了带有腙片段的衍生物。一些合成的化合物表现出明显的抗菌活性，并且发现 3-[(4-氧代-4,5-二氢-1,3-噻唑-2-基)(苯基)氨基]丙酸能促进油菜生长，提高种子产量和含油率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e874/6269796/c6361b3f3df0/molecules-18-15000-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e874/6269796/5b7a90562efc/molecules-18-15000-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e874/6269796/be93d6fd86a6/molecules-18-15000-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e874/6269796/c6361b3f3df0/molecules-18-15000-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e874/6269796/5b7a90562efc/molecules-18-15000-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e874/6269796/be93d6fd86a6/molecules-18-15000-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e874/6269796/c6361b3f3df0/molecules-18-15000-g003.jpg

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