Kim Soo Kyung, Kim Hae Jin, Hur Kyu Yeon, Choi Sung Hee, Ahn Chul Woo, Lim Sung Kil, Kim Kyung Rae, Lee Hyun Chul, Huh Kap Bum, Cha Bong Soo
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Am J Clin Nutr. 2004 Apr;79(4):593-9. doi: 10.1093/ajcn/79.4.593.
Visceral obesity is closely associated with cardiovascular disease and the metabolic syndrome. Estimating the amount of visceral fat is important and requires a straightforward, reliable, and practical method.
We investigated whether visceral fat thickness (VFT) measured by ultrasonography can adequately assess visceral fat accumulation and predict cardiovascular or metabolic diseases.
Diabetic patients (240 men and 106 women) underwent ultrasonography to estimate visceral fat accumulation.
The visceral adipose tissue area had the best correlation with VFT (r = 0.799, P < 0.001). VFT correlated with HDL-cholesterol, triacylglycerol, and high-sensitivity C-reactive protein concentrations, the homeostasis model assessment for insulin resistance, and the intima-media thickness at the common carotid artery (r = -0.30, 0.39, 0.34, 0.31, and 0.33, respectively; P < 0.05) in men and with triacylglycerol and high-sensitivity C-reactive protein concentrations and the homeostasis model assessment for insulin resistance (r = 0.33, 0.44, and 0.30, respectively; P < 0.05) in women. Men in the middle and high VFT tertiles had a higher odds ratio (OR) of coronary artery disease [ORs: 4.48 (95% CI: 1.29, 5.51) and 2.04 (1.06, 3.94), respectively; P = 0.016], hypertriacylglycerolemia [ORs: 2.87 (1.41, 5.86) and 1.91 (1.24, 2.95), respectively; P = 0.003], and the metabolic syndrome [ORs: 3.38 (1.61, 7.10) and 1.95 (1.16, 3.27), respectively; P = 0.003] than did those in the low tertile, after adjustment for age, waist circumference, and body mass index.
VFT might be a reliable index for assessing the amount of visceral fat and for identifying diabetic patients, particularly men, who are at high risk of cardiovascular disease.
内脏肥胖与心血管疾病及代谢综合征密切相关。估算内脏脂肪量很重要，且需要一种直接、可靠且实用的方法。
我们研究了通过超声测量的内脏脂肪厚度（VFT）能否充分评估内脏脂肪堆积情况，并预测心血管或代谢疾病。
糖尿病患者（240名男性和106名女性）接受超声检查以估算内脏脂肪堆积情况。
内脏脂肪组织面积与VFT的相关性最佳（r = 0.799，P < 0.001）。在男性中，VFT与高密度脂蛋白胆固醇、三酰甘油和高敏C反应蛋白浓度、胰岛素抵抗的稳态模型评估以及颈总动脉内膜中层厚度相关（r分别为 -0.30、0.39、0.34、0.31和0.33；P < 0.05）；在女性中，VFT与三酰甘油和高敏C反应蛋白浓度以及胰岛素抵抗的稳态模型评估相关（r分别为0.33、0.44和0.30；P < 0.05）。在对年龄、腰围和体重指数进行校正后，VFT处于中、高三分位数的男性患冠状动脉疾病的比值比（OR）更高[OR分别为：4.48（95%CI：1.29，5.51）和2.04（1.06，3.94）；P = 0.016]，患高甘油三酯血症的OR更高[OR分别为：2.87（1.41，5.86）和1.91（1.24，2.95）；P = 0.003]，患代谢综合征的OR更高[OR分别为：3.38（1.61，7.10）和1.95（1.16，3.27）；P = 0.003]，而VFT处于低三分位数的男性则较低。
VFT可能是评估内脏脂肪量以及识别心血管疾病高危糖尿病患者（尤其是男性）的可靠指标。
