Westaby Stephen
Department of Cardiac Surgery, Oxford Heart Centre, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK.
Surg Clin North Am. 2004 Feb;84(1):179-99, x. doi: 10.1016/S0039-6109(03)00207-X.
This article first discusses coronary artery disease, including left-ventricular dysfunction, hibernating myocardium, the relationship between stunning, hibernation, and heart failure, and molecular mechanisms underlying myocardial hibernation. Left ventricular function and the prognosis and pathophysiology of left-ventricular dysfunction are then examined. Selection of patients for revascularization is discussed, to include which coronary patients should be investigated for myocardial viability, and other surgical considerations are outlined. The outcome following revascularization in the heart failure patient, the results of revascularization, and the time course of functional recovery after coronary artery bypass graft are also covered.
本文首先讨论冠状动脉疾病,包括左心室功能障碍、冬眠心肌、心肌顿抑、冬眠与心力衰竭之间的关系以及心肌冬眠的分子机制。接着探讨左心室功能以及左心室功能障碍的预后和病理生理学。讨论了血管重建患者的选择,包括哪些冠心病患者应进行心肌存活性检查,并概述了其他手术注意事项。还涵盖了心力衰竭患者血管重建后的结果、血管重建的效果以及冠状动脉搭桥术后功能恢复的时间进程。