Gan D D, Macaluso M, Cinti C, Khalili K, Giordano A
Center for NeuroVirology and Cancer Biology, Dept. of Biology, Temple University, Philadelphia, PA 19122, USA.
J Exp Clin Cancer Res. 2003 Dec;22(4):509-16.
The mechanism by which cells become cancerous has been studied in several different species and cell types. Here, we will focus on the mechanism by which a normal human cell becomes a cancer cell and specifically discuss genes that researchers have used to transform cells. Studying how those genes affect cellular immortalization and transformation will help researchers understand more about cancer biology, find new treatments for cancer and/or improve cell survival during gene therapy.
细胞癌变的机制已在几种不同的物种和细胞类型中进行了研究。在此，我们将重点关注正常人类细胞转变为癌细胞的机制，并具体讨论研究人员用于转化细胞的基因。研究这些基因如何影响细胞永生化和转化，将有助于研究人员更深入地了解癌症生物学，找到新的癌症治疗方法和/或改善基因治疗期间的细胞存活情况。
