Konnikova Liza, Simeone Marina C, Kruger Matthew M, Kotecki Maciej, Cochran Brent H
Department of Physiology, Tufts University, Boston, Massachusetts 02111, USA.
Cancer Res. 2005 Aug 1;65(15):6516-20. doi: 10.1158/0008-5472.CAN-05-0924.
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that plays a critical role in cytokine and growth factor signaling and is frequently activated in human tumors. Human telomerase reverse transcriptase (hTERT) is also often overexpressed in tumor cells and mediates cellular immortalization. Here we report that STAT3 directly regulates the expression of hTERT in a variety of human cancer cells. Moreover, STAT3 activity is required for the survival of many human tumors, and hTERT expression contributes to the survival of STAT3-dependent tumor cells. In addition, we find that growth factors and cytokines stimulate hTERT expression in primary human cells in a STAT3-dependent manner. Thus, STAT3 is a key regulator of hTERT expression in both normal and tumor cells.
信号转导与转录激活因子3（STAT3）是一种转录因子，在细胞因子和生长因子信号传导中起关键作用，且在人类肿瘤中经常被激活。人类端粒酶逆转录酶（hTERT）在肿瘤细胞中也常过度表达，并介导细胞永生化。在此我们报告，STAT3在多种人类癌细胞中直接调控hTERT的表达。此外，STAT3活性是许多人类肿瘤存活所必需的，而hTERT表达有助于STAT3依赖性肿瘤细胞的存活。另外，我们发现生长因子和细胞因子以STAT3依赖性方式刺激原代人类细胞中的hTERT表达。因此，STAT3是正常细胞和肿瘤细胞中hTERT表达的关键调节因子。
