Bell-McGinty Sandra, Habeck Christian, Hilton H John, Rakitin Brian, Scarmeas Nikolaos, Zarahn Eric, Flynn Joseph, DeLaPaz Robert, Basner Robert, Stern Yaakov
Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer's Disease and the Aging Brain, 630 West 168th Street, PH-18, New York, USA.
Cereb Cortex. 2004 May;14(5):496-502. doi: 10.1093/cercor/bhh011. Epub 2004 Mar 28.
The study aimed to identify task-related brain activation networks whose change in expression exhibits subject differences as a function of differential susceptibility to sleep deprivation. Brain activity during a non-verbal recognition memory task was investigated in an event-related functional MRI paradigm both prior to and after 48 h of sleep deprivation. Nineteen healthy subjects participated. Regional covariance analysis was applied to data. An activation network pattern was identified whose expression decreased from pre- to post-sleep deprivation in 15 out 19 subjects (P < 0.05). Differential decrease in expression correlated with worsening performance in recognition accuracy (P < 0.05). Sites of de-activation were found in the posterior cerebellum, right fusiform gyrus and precuneus, and left lingual and inferior temporal gyri; increased activation was found in the bilateral insula, claustrum and right putamen. A network whose expression decreased after sleep deprivation and correlated with memory performance was identified. We conclude that this activation network plays a role in cognitive function during sleep deprivation.
该研究旨在识别与任务相关的大脑激活网络，其表达变化表现出个体差异，且这种差异是睡眠剥夺易感性不同的函数。在一项事件相关功能磁共振成像范式中，于睡眠剥夺48小时前后，对一项非言语识别记忆任务期间的大脑活动进行了研究。19名健康受试者参与其中。对数据应用了区域协方差分析。确定了一种激活网络模式，在19名受试者中有15名其表达从睡眠剥夺前到睡眠剥夺后有所下降（P < 0.05）。表达的差异下降与识别准确性的性能恶化相关（P < 0.05）。失活部位见于小脑后部、右侧梭状回和楔前叶，以及左侧舌回和颞下回；双侧岛叶、屏状核和右侧壳核出现激活增加。识别出一个在睡眠剥夺后表达下降且与记忆表现相关的网络。我们得出结论，该激活网络在睡眠剥夺期间的认知功能中发挥作用。
