Yin Ying, Chen Shufang, Song Tao, Zhou Qianxiang, Shao Yongcong
Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
School of Psychology, Beijing Sport University, Beijing 100084, China.
Brain Sci. 2023 Jun 1;13(6):898. doi: 10.3390/brainsci13060898.
: The function of working memory (WM) is impaired by total sleep deprivation (TSD) and cognitive load. However, it is unclear whether the load modulates the effect of TSD on WM. We conducted a pilot study to investigate the effects of 36 h of TSD on WM under different load levels. Twenty-two male students aged 18-25 years were enrolled, who underwent two types of sleep conditions (baseline and 36 h TSD), where they performed two N-back WM tasks (one-back task and two-back task) with simultaneous electroencephalography recordings. Repeated measures analysis of variance (ANOVA) indicated that, with the increasing load, the reaction time increased and the accuracy decreased. After TSD, the correct number per unit time decreased. The significant interaction effect of the P3 amplitudes between the load level and the sleep condition showed that the reduction in the amplitude of P3 in the two-back task due to TSD was more obvious than that in the one-back task. Our results provided evidence for the moderation of load on the impairment of TSD on WM. The degree of TSD-induced impairment for a higher load was greater than that for a lower load. The current study provides new insights into the mechanisms by which sleep deprivation affects cognitive function.
工作记忆（WM）的功能会因完全睡眠剥夺（TSD）和认知负荷而受损。然而，尚不清楚负荷是否会调节TSD对WM的影响。我们进行了一项初步研究，以调查36小时TSD在不同负荷水平下对WM的影响。招募了22名年龄在18至25岁之间的男性学生，他们经历了两种睡眠条件（基线和36小时TSD），在此期间他们进行了两项n-back WM任务（单背任务和双背任务），同时进行脑电图记录。重复测量方差分析（ANOVA）表明，随着负荷增加，反应时间增加而准确性降低。TSD后，单位时间内的正确次数减少。负荷水平和睡眠条件之间P3振幅的显著交互作用表明，TSD导致双背任务中P3振幅的降低比单背任务中更明显。我们的结果为负荷对TSD损害WM的调节作用提供了证据。TSD对较高负荷引起的损害程度大于对较低负荷的损害程度。当前的研究为睡眠剥夺影响认知功能的机制提供了新的见解。
