Weinstein Stephanie J, Vogt Tara M, Gerrior Shirley A
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Insititue, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
J Am Diet Assoc. 2004 Apr;104(4):576-84. doi: 10.1016/j.jada.2004.01.005.
The Healthy Eating Index (HEI) is a summary measure of dietary quality, based on a 100-point scale. Our objectives were to assess the HEI as a measure of dietary status through its correlation with nutritional biomarkers and to identify those biomarkers most associated with diet quality and healthful food intake patterns.
National Health and Nutrition Examination Survey (NHANES) III, 1988-94.
Adults (> or =17 years) with calculated HEI scores and blood nutrient data (n=16,467).
Weighted crude and partial Pearson correlation coefficients (r) between HEI scores and blood nutrients were calculated. Geometric mean blood nutrient concentrations were calculated for five HEI score categories (ranging from < or =50 to >80).
HEI score was positively correlated with serum (r=0.25) and red blood cell (r=0.27) folate, serum vitamins C (r=0.30) and E (r=0.21), and all serum carotenoids except lycopene (r=0.17 to 0.27). These blood nutrient concentrations were 21% to 175% higher for participants in the highest HEI score group (>80) compared with those in the lowest group (< or =50). Mean HEI scores were significantly (P<.0001) greater among the 42% of participants who took dietary supplements. Most correlations were attenuated when adjusted for additional factors.
HEI score is correlated with a wide range of blood nutrients; the strongest relationships are with biomarkers of fruit and vegetable intake. These results are an important step in the validation of the HEI, emphasizing its potential as a tool for nutrition and health studies.
健康饮食指数（HEI）是基于100分制的饮食质量综合衡量指标。我们的目的是通过其与营养生物标志物的相关性来评估HEI作为饮食状况衡量指标，并确定那些与饮食质量和健康食物摄入模式最相关的生物标志物。
1988 - 1994年全国健康与营养检查调查（NHANES）III。
具有计算得出的HEI分数和血液营养数据的成年人（≥17岁）（n = 16467）。
计算HEI分数与血液营养素之间的加权粗Pearson相关系数（r）和偏Pearson相关系数（r）。计算了五个HEI分数类别（范围从≤50到＞80）的几何平均血液营养素浓度。
HEI分数与血清（r = 0.25）和红细胞（r = 0.27）叶酸、血清维生素C（r = 0.30）和维生素E（r = 0.21）以及除番茄红素外的所有血清类胡萝卜素（r = 0.17至0.27）呈正相关。与最低分数组（≤50）的参与者相比，最高HEI分数组（＞80）的参与者的这些血液营养素浓度高出21%至175%。在服用膳食补充剂的42%的参与者中，平均HEI分数显著更高（P <.0001）。在调整其他因素后，大多数相关性减弱。
HEI分数与多种血液营养素相关；最强的关系是与水果和蔬菜摄入量的生物标志物相关。这些结果是HEI验证中的重要一步，强调了其作为营养与健康研究工具的潜力。
