Mathur Hiru, Moretti Antonio J, Flaitz Catherine M
University of Texas Health Science Center, Houston Dental Branch, Department of Endodontics and Periodontics, USA.
Gen Dent. 2003 Mar-Apr;51(2):159-62.
Immunosuppressive therapy with cyclosporin has been known to cause gingival overgrowth in humans. It usually is not feasible to suspend this therapy to treat the adverse side effect. This case report describes a renal transplant patient who had used both cyclosporin and nifedipine for more than 10 years but had to discontinue immunosuppressive drug therapy due to organ rejection. Discontinuing therapy led to almost complete regression of the gingival overgrowth in a few months after interruption of cyclosporin therapy only. These findings suggest that the discontinuation of cyclosporin results in the reversal of gingival overgrowth without surgical intervention and may be the most definitive form of therapy for this condition in susceptible individuals as new drugs become available.
已知环孢素免疫抑制疗法会导致人类牙龈增生。通常，暂停这种疗法来治疗不良反应并不可行。本病例报告描述了一名肾移植患者，该患者同时使用环孢素和硝苯地平超过10年，但因器官排斥不得不停止免疫抑制药物治疗。仅在停用环孢素治疗后的几个月内，停止治疗就导致牙龈增生几乎完全消退。这些发现表明，停用环孢素可在无需手术干预的情况下使牙龈增生逆转，并且随着新药的出现，对于易感个体而言，这可能是治疗这种病症最有效的疗法。
