Martignoni Emilia, Nappi Rossella E, Citterio Antonietta, Calandrella Daniela, Zangaglia Roberta, Mancini Francesca, Corengia Elisabetta, Riboldazzi Giulio, Polatti Franco, Nappi Giuseppe
Parkinson's Disease and Movement Disorders Unit, IRCCS C. Mondino Institute of Neurology, Pavia, Italy.
Funct Neurol. 2003 Oct-Dec;18(4):211-7.
Reproductive life milestones were studied in 150 unselected women with idiopathic Parkinson's disease (PD) and in 300 postmenopausal healthy women (PM). Duration of reproductive life was found to be similar in the two groups. The women with PD reported significantly more premenstrual symptoms, fewer deliveries and abortions, and less use of contraception. Time and mode of menopause onset were similar in PD and PM, but the PD women reported significantly more hot flushes, less insomnia, depression, urinary incontinence and dyspareunia, and less recourse to hormone replacement therapy than the PM women. Women diagnosed with PD before the menopause reported more premenstrual symptoms and contraceptive use compared with those with postmenopausal PD onset, as well as a premenstrual worsening of PD symptoms in more than 50% of cases. Our data indicate poor adaptation of neuronal pathways to the hormonal fluctuations of reproductive life in women with PD, supporting the existence of a qualitative relationship between PD and reproductive events.
对150名未经过挑选的特发性帕金森病（PD）女性患者和300名绝经后健康女性（PM）的生殖生命里程碑进行了研究。发现两组的生殖生命时长相似。PD组女性报告的经前症状明显更多，分娩和流产次数更少，避孕措施使用也更少。PD组和PM组绝经开始的时间和方式相似，但PD组女性报告的潮热明显更多，失眠、抑郁、尿失禁和性交困难更少，且与PM组女性相比，求助于激素替代疗法的情况也更少。与绝经后才发病的PD女性相比，绝经前被诊断为PD的女性报告的经前症状和避孕措施使用更多，并且超过50%的病例中存在经前PD症状加重的情况。我们的数据表明，PD女性患者的神经元通路对生殖生命中的激素波动适应不良，支持了PD与生殖事件之间存在质性关系的观点。
