Ragonese Paolo, D'Amelio Marco, Callari Graziella, Salemi Giuseppe, Morgante Letterio, Savettieri Giovanni
Dipartimento di Neuroscienze Cliniche, University of Palermo, Palermo, Italy.
Mov Disord. 2006 Dec;21(12):2211-4. doi: 10.1002/mds.21127.
We investigated the association between age at onset of Parkinson's disease (PD) and fertile life characteristics in 145 women. Linear regression analyses showed a significant correlation between age at PD onset and age at menopause (P = 0.003), between age at PD onset and fertile life duration (P = 0.008), and a nonsignificant correlation between PD onset and cumulative duration of pregnancies (P = 0.23). These results support the possible role of estrogens in PD.
我们研究了145名女性帕金森病（PD）发病年龄与生育期特征之间的关联。线性回归分析显示，PD发病年龄与绝经年龄之间存在显著相关性（P = 0.003），PD发病年龄与生育期持续时间之间存在显著相关性（P = 0.008），而PD发病与累计妊娠持续时间之间无显著相关性（P = 0.23）。这些结果支持了雌激素在PD中可能发挥的作用。
