绝经年龄可预测帕金森病的发病年龄。
Age at menopause predicts age at onset of Parkinson's disease.
作者信息
Ragonese Paolo, D'Amelio Marco, Callari Graziella, Salemi Giuseppe, Morgante Letterio, Savettieri Giovanni
机构信息
Dipartimento di Neuroscienze Cliniche, University of Palermo, Palermo, Italy.
出版信息
Mov Disord. 2006 Dec;21(12):2211-4. doi: 10.1002/mds.21127.
We investigated the association between age at onset of Parkinson's disease (PD) and fertile life characteristics in 145 women. Linear regression analyses showed a significant correlation between age at PD onset and age at menopause (P = 0.003), between age at PD onset and fertile life duration (P = 0.008), and a nonsignificant correlation between PD onset and cumulative duration of pregnancies (P = 0.23). These results support the possible role of estrogens in PD.
我们研究了145名女性帕金森病（PD）发病年龄与生育期特征之间的关联。线性回归分析显示，PD发病年龄与绝经年龄之间存在显著相关性（P = 0.003），PD发病年龄与生育期持续时间之间存在显著相关性（P = 0.008），而PD发病与累计妊娠持续时间之间无显著相关性（P = 0.23）。这些结果支持了雌激素在PD中可能发挥的作用。
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