生殖因素与帕金森病：一项多中心病例对照研究。

Reproductive factors and Parkinson's disease: a multicenter case-control study.

机构信息

Dipartimento Ingrassia Sezione di Neuroscienze, Università di Catania, Catania, Italy.

出版信息

Mov Disord. 2011 Dec;26(14):2563-6. doi: 10.1002/mds.23951. Epub 2011 Sep 28.

DOI:10.1002/mds.23951

PMID:21956541

Abstract

BACKGROUND

The objective of this study was to evaluate the possible association between endogenous and exogenous estrogens and Parkinson's disease (PD).

METHODS

The FRAGAMP study is a large Italian multicenter case-control study. PD was diagnosed according to Gelb's criteria. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. Adjusted ORs and 95% CIs were estimated using multivariate analysis (logistic regression).

RESULTS

Two hundred PD women (mean age, 68.0 ± 9.5 years) and 299 control women (mean age, 61.8 ± 9.9 years) were enrolled in the study. Age at menarche, age at menopause, fertile life duration, cumulative duration of pregnancies, hormone replacement therapy, and surgical menopause were not significantly associated with PD. Multivariate analysis showed a significant positive association between use of oral contraceptives and PD, with an adjusted OR of 3.27 (95% CI, 1.24-8.59; P = .01).

CONCLUSIONS

Our data suggest that oral contraceptives could increase the risk of PD.

摘要

背景

本研究旨在评估内源性和外源性雌激素与帕金森病（PD）之间可能存在的关联。

方法

FRAGAMP 研究是一项大型的意大利多中心病例对照研究。PD 的诊断依据是 Gelb 标准。采用标准化问卷记录人口统计学、流行病学和临床数据。采用多变量分析（logistic 回归）估计调整后的 OR 值和 95%CI。

结果

本研究纳入了 200 名 PD 女性（平均年龄 68.0 ± 9.5 岁）和 299 名对照女性（平均年龄 61.8 ± 9.9 岁）。初潮年龄、绝经年龄、生育期、妊娠总持续时间、激素替代疗法和手术绝经与 PD 无显著相关性。多变量分析显示，口服避孕药的使用与 PD 显著相关，调整后的 OR 值为 3.27（95%CI，1.24-8.59；P =.01）。