Spear Patricia G
Feinberg School of Medicine of Northwestern University, Chicago, IL 60611, USA.
Cell Microbiol. 2004 May;6(5):401-10. doi: 10.1111/j.1462-5822.2004.00389.x.
Entry of herpes simplex virus (HSV) into cells depends upon multiple cell surface receptors and multiple proteins on the surface of the virion. The cell surface receptors include heparan sulphate chains on cell surface proteoglycans, a member of the tumor necrosis factor (TNF) receptor family and two members of the immunoglobulin superfamily related to the poliovirus receptor. The HSV ligands for these receptors are the envelope glycoproteins gB and gC for heparan sulphate and gD for the protein receptors and specific sites in heparan sulphate generated by certain 3-O-sulfotransferases. HSV gC also binds to the C3b component of complement and can block complement-mediated neutralization of virus. The purposes of this review are to summarize available information about these cell surface receptors and the viral ligands, gC and gD, and to discuss roles of these viral glycoproteins in immune evasion and cellular responses as well as in viral entry.
单纯疱疹病毒（HSV）进入细胞取决于多种细胞表面受体以及病毒体表面的多种蛋白质。细胞表面受体包括细胞表面蛋白聚糖上的硫酸乙酰肝素链、肿瘤坏死因子（TNF）受体家族的一个成员以及与脊髓灰质炎病毒受体相关的免疫球蛋白超家族的两个成员。这些受体的HSV配体是硫酸乙酰肝素的包膜糖蛋白gB和gC、蛋白质受体的gD以及某些3-O-磺基转移酶产生的硫酸乙酰肝素中的特定位点。HSV gC还与补体的C3b成分结合，并可阻断补体介导的病毒中和作用。本综述的目的是总结有关这些细胞表面受体以及病毒配体gC和gD的现有信息，并讨论这些病毒糖蛋白在免疫逃避、细胞反应以及病毒进入中的作用。
