Ramos-Kuri J M
Laboratorio de Neurovirología, Instituto Nacional de Neurología y Neurocirugía, México D.F.
Rev Latinoam Microbiol. 1992 Jan-Mar;34(1):23-31.
A bibliographic update on the herpes simplex virus (HSV) envelope is made with special emphasis on the membrane glycoproteins and their role in adsorption, spreading and escape of the immune response. The HSV has at least seven glycoproteins on its envelope; three out of them are essential for in vitro replication, they are designated as gB, gD and gH; four are dispensable: gC, gE, gI and gG. Their main functions are: gC, gB and gD attach the virion to the cell surface, binding to molecules of heparan sulfate on the plasma membrane. Later, the three essential glycoproteins induce fusion of the viral envelope with the plasma membrane, through the gD receptor. To evade the immune response, the HSV has two major mechanisms: gE and gI are Fc receptors of immunoglobulin G; while gC acts as a receptor for the C3b fragment of the third component of complement. Finally, gG and gC have epitopes responsible for the antigenic differences between HSV type 1 and HSV-2. These glycoproteins have several possible applications for the development of a synthetic vaccine, and for treatment of herpetic recurrent disease.
对单纯疱疹病毒（HSV）包膜进行文献综述更新，特别强调膜糖蛋白及其在吸附、传播和逃避免疫反应中的作用。HSV包膜上至少有七种糖蛋白；其中三种对体外复制至关重要，分别命名为gB、gD和gH；另外四种则非必需：gC、gE、gI和gG。它们的主要功能如下：gC、gB和gD使病毒粒子附着于细胞表面，与质膜上的硫酸乙酰肝素分子结合。随后，这三种必需糖蛋白通过gD受体诱导病毒包膜与质膜融合。为逃避免疫反应，HSV有两种主要机制：gE和gI是免疫球蛋白G的Fc受体；而gC作为补体第三成分C3b片段的受体。最后，gG和gC具有导致1型HSV和2型HSV抗原差异的表位。这些糖蛋白在合成疫苗开发和疱疹复发性疾病治疗方面有多种潜在应用。
