Kohen Dora
Lancashire Postgraduate School of Medicine and Health, Psychiatric Department, Mental Health Management Block, Leigh Infirmary, Leigh WN7 1HS, UK.
Br J Psychiatry Suppl. 2004 Apr;47:S64-6. doi: 10.1192/bjp.184.47.s64.
Although recent research has focused on the possible role of antipsychotic medications in the development of diabetes mellitus, studies conducted in the pre-neuroleptic era suggest that schizophrenia itself might predispose individuals to diabetes.
To test the hypothesis that diabetes mellitus is an integral part of schizophrenia.
Historical literature review.
Many people with severe mental illnesses, including dementia praecox, showed abnormal responses to insulin and diabetes-like glucose tolerance curves long before the advent of phenothiazines. Early studies with chlorpromazine suggested that a latent tendency towards diabetes in patients with schizophrenia could be unmasked by this treatment.
Diabetes and disturbed carbohydrate metabolism may be an integral part of schizophrenia. Further research is required to explain how metabolic factors, medications and lifestyle factors might precipitate diabetes in patients with this mental disorder.
尽管近期研究聚焦于抗精神病药物在糖尿病发生过程中可能扮演的角色，但在使用抗精神病药物之前的时代所开展的研究表明，精神分裂症本身可能使个体易患糖尿病。
检验糖尿病是精神分裂症一个固有组成部分这一假说。
历史文献回顾。
早在吩噻嗪类药物出现之前，许多患有严重精神疾病（包括早发性痴呆）的人就表现出对胰岛素的异常反应以及类似糖尿病的糖耐量曲线。早期使用氯丙嗪的研究表明，这种治疗可能会揭示精神分裂症患者潜在的糖尿病倾向。
糖尿病和碳水化合物代谢紊乱可能是精神分裂症的一个固有组成部分。需要进一步研究来解释代谢因素、药物和生活方式因素如何促使患有这种精神障碍的患者患糖尿病。
