Assmann G, Schulte H
Institut für Klinische Chemie und Laboratoriumsmedizin, Universität Münster, Germany.
Eur J Epidemiol. 1992 May;8 Suppl 1:99-103. doi: 10.1007/BF00145359.
In the PROCAM study hypertriglyceridaemia was much more common among men (18.6%) than women (4.2%). Prevalence increased with age in women, but remained nearly constant at about 20% in men aged 35 years or more. In a multiple regression analysis a strong negative correlation between triglycerides and HDL cholesterol was found. A positive relationship was observed with cholesterol, blood glucose, factor VIIc, and PAI-1 in both sexes. Only in men, triglycerides are positively correlated with Apo A-I, body mass index, cigarette smoking, and alcohol consumption. Postmenopausal women showed higher triglyceride levels than premenopausal women. No independent relationships were observed to age, blood pressure, Lp(a), Apo A-II, Apo B, AT-III, protein C, fibrinogen, and oral contraceptives. A longitudinal analysis of data from 4474 male PROCAM participants aged 40-64 years with a follow-up of 4 years did not identify triglycerides as an independent risk factor, but the data suggest hypertriglyceridaemia is an additional risk factor for CHD, when excessive triglycerides coincide with a high ratio of plasma cholesterol to HDL-cholesterol and with low HDL-cholesterol values.
在 PROCAM 研究中，高甘油三酯血症在男性中（18.6%）比女性中（4.2%）更为常见。女性的患病率随年龄增加，而 35 岁及以上男性的患病率则几乎保持在 20%左右不变。在多元回归分析中，发现甘油三酯与高密度脂蛋白胆固醇之间存在强烈的负相关。在两性中均观察到甘油三酯与胆固醇、血糖、凝血因子 VIIc 和纤溶酶原激活物抑制剂 -1 呈正相关。仅在男性中，甘油三酯与载脂蛋白 A-I、体重指数、吸烟和饮酒呈正相关。绝经后女性的甘油三酯水平高于绝经前女性。未观察到甘油三酯与年龄、血压、脂蛋白(a)、载脂蛋白 A-II、载脂蛋白 B、抗凝血酶 III、蛋白 C、纤维蛋白原及口服避孕药之间存在独立关系。对 4474 名年龄在 40 - 64 岁的男性 PROCAM 参与者进行的为期 4 年的随访纵向数据分析未将甘油三酯确定为独立危险因素，但数据表明，当甘油三酯过高与血浆胆固醇与高密度脂蛋白胆固醇的高比值以及低高密度脂蛋白胆固醇值同时出现时，高甘油三酯血症是冠心病的一个额外危险因素。
