El Saghir Nagi S, Otrock Zaher K
Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Anticancer Drugs. 2004 Apr;15(4):401-4. doi: 10.1097/00001813-200404000-00013.
We report a new case of central line extravasation of docetaxel into the normal breast of a patient with metastatic left breast cancer. During the infusion of docetaxel, the patient complained of mild discomfort at the site of a subclavian Port-a-Cath, followed by redness, warmth and itchiness of the entire skin of the right breast beneath the port of entry, and it involved the entire right breast by the next day. Over the following few days, she developed blistering, desquamation and oozing of serous fluid through skin fissures. Anti-histamines and hydrocortisonebased ointment induced partial relief of symptoms. Warm soaks induced skin relief. Reaction resolved over few weeks leaving a brownish pigmentation of the skin of the breast, with clearly demarcated lines, as the only sequlae.
我们报告了一例左乳转移性癌患者发生多西他赛经中心静脉导管渗漏至正常乳腺的新病例。在输注多西他赛期间，患者主诉锁骨下植入式静脉输液港部位有轻度不适，随后输液港入口下方右侧乳房的整个皮肤出现发红、发热和瘙痒，次日累及整个右侧乳房。在接下来的几天里，她出现水疱、脱皮，并通过皮肤裂隙渗出浆液。抗组胺药和含氢化可的松的药膏使症状部分缓解。热敷使皮肤症状减轻。反应在几周内消退，仅留下乳房皮肤呈褐色色素沉着，边界清晰，作为唯一的后遗症。
