Lis Anna D, Brzezińska-Wcisło Ligia A
Katedry i Kliniki Dermatologii Slaskiej Akademii Medycznej w Katowicach.
Wiad Lek. 2003;56(11-12):532-6.
The aim of this study was to examine the levels of some soluble receptors of cytokines in sera from patients with systemic sclerosis (SSc) and to evaluate their role as parameters of disease activity and severity. Fifty-four patients with SSc were included in the study. Concentrations of the soluble receptors: sIL-2R, sTNF alpha RI and sIL-6R were determined by an enzyme-linked immunosorbent assay-ELISA. Controls were healthy age- and sex-matched volunteers. The study demonstrated that soluble receptors levels: sII-2R, sIL-6R and sTNF alpha RI were elevated in SSc patients and correlated with progress and severity of the disease. The most important correlations were found for sIL-2R levels, which were increased in 66.7% of patients. The raised levels of sTNF alpha RI were found in 32.4% of patients, and sIL-6R in 23.7% of patients. The concentrations were elevated in diffuse form of SSc and in patients with rapid systemic progression.
本研究的目的是检测系统性硬化症（SSc）患者血清中某些细胞因子可溶性受体的水平，并评估它们作为疾病活动度和严重程度参数的作用。54例SSc患者纳入本研究。采用酶联免疫吸附测定法（ELISA）测定可溶性受体sIL-2R、sTNFαRI和sIL-6R的浓度。对照组为年龄和性别匹配的健康志愿者。研究表明，SSc患者可溶性受体水平：sII-2R、sIL-6R和sTNFαRI升高，且与疾病进展和严重程度相关。sIL-2R水平的相关性最为显著，66.7%的患者其水平升高。32.4%的患者sTNFαRI水平升高，23.7%的患者sIL-6R水平升高。弥漫型SSc患者及全身进展迅速的患者其浓度升高。
