Ihn H, Sato S, Fujimoto M, Kikuchi K, Takehara K
Department of Dermatology, University of Tokyo, Japan.
Br J Dermatol. 1996 May;134(5):843-7.
Localized scleroderma has been reported to be accompanied by abnormal immune reactions, including autoantibody production and lymphocyte activation. Lymphocyte activation can be quantitatively detected by measuring soluble interleukin-2 receptor (sIL-2R) in serum samples. In this study, serum sIL-2R levels were assayed by a sensitive enzyme-linked immunosorbent assay, in 48 patients with localized scleroderma, in 20 with systemic sclerosis (SSc) and in 20 healthy controls. Serum levels of sIL-2R were significantly higher in patients with localized scleroderma than in healthy controls. The serum levels of sIL-2R were correlated with the number of sclerotic lesions, the number of involved areas, the levels of anti-ssDNA, and the levels of antihistone antibody immunoglobulin M. Moreover, sIL-2R levels in sera from patients with SSc were also significantly higher than in healthy controls. Elevated serum levels of sIL-2R in localized scleroderma suggest that lymphocyte activation is one of the early processes in the development of this disease.
据报道，局限性硬皮病伴有异常免疫反应，包括自身抗体产生和淋巴细胞活化。淋巴细胞活化可通过检测血清样本中的可溶性白细胞介素-2受体（sIL-2R）进行定量检测。在本研究中，采用灵敏的酶联免疫吸附测定法检测了48例局限性硬皮病患者、20例系统性硬化症（SSc）患者和20名健康对照者的血清sIL-2R水平。局限性硬皮病患者的血清sIL-2R水平显著高于健康对照者。血清sIL-2R水平与硬化性病变数量、受累区域数量、抗单链DNA水平以及抗组蛋白抗体免疫球蛋白M水平相关。此外，SSc患者血清中的sIL-2R水平也显著高于健康对照者。局限性硬皮病患者血清sIL-2R水平升高表明淋巴细胞活化是该疾病发生发展的早期过程之一。
