Steen V D, Engel E E, Charley M R, Medsger T A
Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, PA, USA.
J Rheumatol. 1996 Apr;23(4):646-9.
To determine whether soluble interleukin 2 receptor (sIL-2R) levels correlate with natural history of disease in patients with systemic sclerosis (SSc).
The following groups were studied: Group I included 81 consecutive new patients with SSc. Group II consisted of 21 patients with diffuse cutaneous (dc) SSc whose peripheral blood and affected skin had been analyzed for T lymphocyte subsets. Group III contained 38 patients with dcSSc with serial sIL-2R determinations during the course of disease. sIL-2R was performed using a commercial double monoclonal antibody ELISA technique.
The 81 Group I patients with SSc had a mean sIL-2R level of 821 units compared with 35 controls, who had a mean of 389 units (p < 0.001). sIL-2R level significantly correlated with the extent of skin thickening (p < 0.005). In Group II patients, sIL-2R was found to correlate with the CD4 to CD8 ratio. Blindly assessed clinical evidence of disease activity from the serial samples of 38 Group III patients was consistent with sIL-2R levels in 83% of the samples. There was high correlation of change in sIL-2R with change in skin score over time in Group III subjects (r = 0.71).
These results suggest a role for T cell activation in the pathogenesis of SSc. sIL-2R levels may be useful adjunct to clinical evaluation in assessing disease activity and predicting future events in patients with SSc.
确定可溶性白细胞介素2受体（sIL-2R）水平是否与系统性硬化症（SSc）患者的疾病自然史相关。
研究了以下几组：第一组包括81例连续的SSc新患者。第二组由21例弥漫性皮肤型（dc）SSc患者组成，其外周血和受累皮肤已进行T淋巴细胞亚群分析。第三组包含38例dcSSc患者，在疾病过程中进行了系列sIL-2R测定。使用商业双单克隆抗体ELISA技术检测sIL-2R。
81例第一组SSc患者的平均sIL-2R水平为821单位，而35例对照组的平均水平为389单位（p < 0.001）。sIL-2R水平与皮肤增厚程度显著相关（p < 0.005）。在第二组患者中，发现sIL-2R与CD4/CD8比值相关。对38例第三组患者的系列样本进行的盲法评估的疾病活动临床证据与83%的样本中的sIL-2R水平一致。第三组受试者中，sIL-2R的变化与皮肤评分随时间的变化高度相关（r = 0.71）。
这些结果提示T细胞活化在SSc发病机制中起作用。sIL-2R水平可能是评估SSc患者疾病活动和预测未来事件的临床评估的有用辅助指标。
