Votruba J, Páca J
Institute of Microbiology, Czechoslovak Academy of Sciences, Prague.
Folia Microbiol (Praha). 1992;37(2):133-9. doi: 10.1007/BF02836618.
The mathematical theory of substrate-induced acidification by microorganisms was based on special formulation of mass and charge conservation laws for distinct species. The strength of the theory was tested on the ethanol-induced acidification by Candida utilis in pure water and in phthalate buffer. We showed that the theory may be used to approximate, extrapolate and predict the course of apparent acidification including the effects of buffering capacity of the broth. It makes it possible to formulate mathematical models that are suitable for process simulation and computer control of bioreactors when pH is used as a state variable.
微生物引起的底物诱导酸化的数学理论基于对不同物种质量和电荷守恒定律的特殊表述。该理论的有效性在产朊假丝酵母在纯水和邻苯二甲酸盐缓冲液中引起的乙醇诱导酸化实验中得到了验证。我们表明，该理论可用于近似、推断和预测表观酸化过程，包括肉汤缓冲能力的影响。当将pH用作状态变量时，这使得构建适用于生物反应器过程模拟和计算机控制的数学模型成为可能。
