新一代抗蠕虫化合物的筛选。对线虫秀丽隐杆线虫进行伊维菌素抗性的体外筛选。
Screening for a new generation of anthelminthic compounds. In vitro selection of the nematode Caenorhabditis elegans for ivermectin resistance.
作者信息
Novák J, Vanĕk Z
机构信息
Institute of Microbiology, Czechoslovak Academy of Sciences, Prague.
出版信息
Folia Microbiol (Praha). 1992;37(3):237-8. doi: 10.1007/BF02933156.
PMID:1505886
Abstract
Development of resistance to ivermectin in vitro is reported for the first time. Two strains of Caenorhabditis elegans D5 and D6 able to grow on agar plates after treating with up to 3 mg ivermectin per L were selected. The parent strain N2 was extremely sensitive to ivermectin, its growth being inhibited by treatment with 0.1-0.2 mg IVM per L.
摘要
首次报道了在体外对伊维菌素产生抗性的情况。选择了两株秀丽隐杆线虫D5和D6，它们在每升高达3毫克伊维菌素处理后能够在琼脂平板上生长。亲本菌株N2对伊维菌素极其敏感，每升0.1 - 0.2毫克伊维菌素的处理会抑制其生长。
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