秀丽隐杆线虫的遗传学
The genetics of Caenorhabditis elegans.
作者信息
Brenner S
出版信息
Genetics. 1974 May;77(1):71-94. doi: 10.1093/genetics/77.1.71.
Abstract
Methods are described for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm. About 300 EMS-induced mutants affecting behavior and morphology have been characterized and about one hundred genes have been defined. Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large.
摘要
本文描述了用于秀丽隐杆线虫（一种小型自由生活的线虫）突变体的分离、互补和定位的方法。已对约300个影响行为和形态的经甲基磺酸乙酯（EMS）诱导的突变体进行了表征，并定义了约100个基因。其中77个突变会改变动物的运动。对可见突变体和X染色体致死突变的诱导突变频率的估计表明，就像在果蝇中一样，秀丽隐杆线虫中的遗传单位很大。
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