Baust J G, Gage A A
Institute of Biomedical Technology, State University of New York, Binghamton, NY 13902 USA.
Technol Cancer Res Treat. 2004 Apr;3(2):95-101. doi: 10.1177/153303460400300202.
Cryosurgery for diverse neoplastic and non-neoplastic diseases has expanded in applicability in recent years, especially since intraoperative ultrasound became available as a method of monitoring the process of tissue freezing. However, persistence of disease after presumably adequate cryosurgical treatment has disclosed deficiencies in the technique, perhaps due to faulty application of the freeze-thaw cycles or due to shortcomings in the imaging method. Clearly cryosurgical technique is less than optimal. The optimal dosimetry for tissue freezing, the recent improvements in imaging techniques, and the need for adjunctive therapy are defined in this review, which assesses the progress toward improving the efficacy of cryosurgery.
近年来，冷冻手术在多种肿瘤性和非肿瘤性疾病中的应用范围不断扩大，尤其是自术中超声作为一种监测组织冷冻过程的方法问世以来。然而，在经过推测认为足够的冷冻手术治疗后疾病仍持续存在，这揭示了该技术存在缺陷，可能是由于冻融循环应用不当或成像方法存在不足。显然，冷冻手术技术并非最佳。本综述定义了组织冷冻的最佳剂量测定法、成像技术的最新进展以及辅助治疗的必要性，该综述评估了在提高冷冻手术疗效方面取得的进展。
