Khan S M, Birch P J, Bass P S, Williams J H, Theaker J M
Department of Histopathology, St. Mary's General Hospital, Portsmouth, UK.
Histopathology. 1992 Aug;21(2):143-7. doi: 10.1111/j.1365-2559.1992.tb00362.x.
A series of nine cases of localized amyloidosis of the lower genitourinary tract are reported. The patients comprised six males and three females with an age range of 50-79 years at initial presentation. Clinically and on cystoscopy, the lesions were often diagnosed as neoplasms. Histologically, seven cases had typical features of localized amyloid deposits, while two cases had an unusual appearance with a florid histiocytic and giant cell reaction. Using an immunoperoxidase staining method the deposits were non-reactive with antibodies to serum amyloid A protein, prealbumin and beta 2 microglobulin, while equivocal immunoreactivity was seen with anti-light chain antibodies.
报告了9例下泌尿生殖道局限性淀粉样变性病例。患者包括6名男性和3名女性，初次就诊时年龄在50至79岁之间。临床及膀胱镜检查时，病变常被诊断为肿瘤。组织学上，7例具有局限性淀粉样沉积物的典型特征，而2例外观异常，伴有明显的组织细胞和巨细胞反应。采用免疫过氧化物酶染色法，沉积物与血清淀粉样A蛋白、前白蛋白和β2微球蛋白抗体无反应，而抗轻链抗体可见不明确的免疫反应性。
