Sant'Angelo D B, Lafuse W P, Passmore H C
Department of Biological Sciences, Rutgers University, Piscataway, New Jersey 08855.
Genomics. 1992 Aug;13(4):1334-6. doi: 10.1016/0888-7543(92)90061-v.
Meiotic recombination in the mouse is sometimes restricted to specific chromosomal sites. For example, when recombinants within the I region of the mouse major histocompatibility complex (MHC) are examined, the breakpoints between standard alleles can usually be mapped to the Eb gene. DNA sequence analysis of five cases of meiotic crossing over associated with this gene suggests that the recombinational hot spot may be confined to large regions of nucleotide identity located within the second intron of the Eb gene.
小鼠的减数分裂重组有时会局限于特定的染色体位点。例如，当检查小鼠主要组织相容性复合体（MHC）I区域内的重组子时，标准等位基因之间的断点通常可定位到Eb基因。对与该基因相关的五例减数分裂交叉的DNA序列分析表明，重组热点可能局限于Eb基因第二内含子内的大片核苷酸相同区域。
