Rappold G A, Trowsdale J, Lichter P
Institut für Humangenetik, University of Heidelberg, Germany.
Genomics. 1992 Aug;13(4):1337-9. doi: 10.1016/0888-7543(92)90062-w.
The gene TCTE3 from the mouse t-complex region is expressed specifically in testicular germ cells. It maps in the central subregion of the t-complex on mouse chromosome 17 containing loci involved in transmission ratio distortion and male sterility. In this study, somatic cell hybrid lines have been used to map the human homologue, TCTE3, to the long arm of chromosome 6. CISS hybridization with the human lambda clone h117 refined this chromosome assignment to the very distal position of chromosome 6q27, thus providing further evidence that loci from the t-complex of mouse chromosome 17 can map to opposite arms of human chromosome 6.
来自小鼠t复合区域的基因TCTE3在睾丸生殖细胞中特异性表达。它定位于小鼠17号染色体t复合区域的中央亚区，该区域包含与传递比失真和雄性不育相关的基因座。在本研究中，利用体细胞杂交系将人类同源基因TCTE3定位到6号染色体长臂。用人类λ克隆h117进行的染色体原位抑制杂交（CISS）将该染色体定位进一步精确到6q27的最远端位置，从而提供了进一步的证据，证明小鼠17号染色体t复合区域的基因座可定位于人类6号染色体的相对臂上。
