Masini Cher V, Holmes Philip V, Freeman Kimberly G, Maki Alexandra C, Edwards Gaylen L
Neuroscience and Behavior Program, Psychology Department, University of Georgia, Athens, GA 30602, USA.
Physiol Behav. 2004 Mar;81(1):111-9. doi: 10.1016/j.physbeh.2004.01.003.
Olfactory bulbectomy (OBX) in rats produces behavioral, physiological, and neurochemical changes that resemble symptoms of depression in humans. The procedure thus serves as a rodent model of affective disorder. Many of the behavioral effects of OBX resemble psychomotor agitation. The possible role of dysregulation of ventral striatal dopamine (DA) systems in this phenomenon was investigated. Basal levels of DA, norepinephrine (NE), homovanillic acid, dihydroxyphenylacetic acid, and 5-hydroxyindoleacetic acid were examined in the striatum of OBX and sham-operated controls using in vivo microdialysis. OBX rats exhibited significantly higher basal DA levels (192%) and lower NE levels (12%) than sham-operated controls. Locomotor activity in response to novelty and footshock stress was elevated in OBX rats. The finding of higher DA levels in striatum may explain this "agitation-like" behavior, a commonly observed phenomenon in the OBX model.
大鼠嗅球切除术（OBX）会引发行为、生理和神经化学变化，这些变化与人类抑郁症症状相似。因此，该手术可作为一种情感障碍的啮齿动物模型。OBX的许多行为效应类似于精神运动性激越。本研究调查了腹侧纹状体多巴胺（DA）系统失调在这一现象中可能发挥的作用。使用体内微透析技术，检测了OBX大鼠和假手术对照组纹状体中DA、去甲肾上腺素（NE）、高香草酸、二羟基苯乙酸和5-羟吲哚乙酸的基础水平。与假手术对照组相比，OBX大鼠的基础DA水平显著升高（192%），而NE水平降低（12%）。OBX大鼠对新奇事物和足部电击应激的运动活动增强。纹状体中DA水平较高这一发现可能解释了这种“激越样”行为，这是OBX模型中常见的现象。
