Rosenberg J C, Lysz K
Proc Clin Dial Transplant Forum. 1977;7:23-8.
An in vitro assay system (MLR-LMC) was used to study the optimal time-concentration characteristics of methylprednisolone as an immunosuppressive drug. Our data suggest that low doses of methylprednisolone (less than 40 mg) most probably contribute little to immunosuppressive therapy and that high doses (15 to 30 mg/kg) are most probably excessive. Clinical trials are necessary to establish the validity of these conclusions and to establish the optimal dose schedule for the administration of steroids to patients undergoing renal transplantation.
采用体外分析系统（MLR-LMC）研究甲基强的松龙作为免疫抑制药物的最佳时间-浓度特性。我们的数据表明，低剂量的甲基强的松龙（小于40毫克）对免疫抑制治疗的作用可能微乎其微，而高剂量（15至30毫克/千克）很可能过量。有必要进行临床试验以证实这些结论的有效性，并确定对接受肾移植患者使用类固醇的最佳给药方案。
