Lee J, Tan C S, Chia K S, Tan C E, Chew S K, Ordovas J M, Tai E S
National University of Singapore-Genome Institute of Singapore Center for Molecular Epidemiology, Community, Occupational and Family Medicine, Singapore.
J Lipid Res. 2004 Jun;45(6):1132-9. doi: 10.1194/jlr.M400016-JLR200. Epub 2004 Apr 1.
We studied 4,058 subjects from a representative sample of the Singapore population 1) to determine the association between the S447X polymorphism at the LPL locus and serum lipid concentration in Chinese, Malays, and Asian Indians living in Singapore and 2) to explore any interactions with apolipoprotein E (APOE) genotype, exercise, obesity, cigarette smoking, and alcohol intake. Information on obesity, lifestyle factors (including smoking, alcohol consumption, and exercise frequency), glucose tolerance, and fasting lipids was obtained. Male and female carriers of the X447 allele had lower serum triglyceride concentrations and higher HDL cholesterol (HDL-C) concentrations. The association between the X447 allele and serum HDL-C concentration was modulated by APOE genotype in males and cigarette smoking and alcohol intake in females. The effect of the X447 allele was greatest in men who carried the E4 allele and women who smoked or consumed alcohol. The X447 allele at the LPL locus is common and associated with a less atherogenic lipid profile in Asian populations. Interactions with APOE genotype, cigarette smoking, and alcohol intake reinforce the importance of examining genetic associations, such as this one, in the context of the population of interest.
我们对来自新加坡人群代表性样本的4058名受试者进行了研究，目的如下：1）确定脂蛋白脂肪酶（LPL）基因座S447X多态性与居住在新加坡的华人、马来人和亚洲印度人的血脂浓度之间的关联；2）探讨与载脂蛋白E（APOE）基因型、运动、肥胖、吸烟和饮酒之间的相互作用。我们获取了有关肥胖、生活方式因素（包括吸烟、饮酒和运动频率）、糖耐量和空腹血脂的信息。X447等位基因的男性和女性携带者血清甘油三酯浓度较低，高密度脂蛋白胆固醇（HDL-C）浓度较高。在男性中，X447等位基因与血清HDL-C浓度之间的关联受APOE基因型调节；在女性中，则受吸烟和饮酒调节。X447等位基因对携带E4等位基因的男性以及吸烟或饮酒的女性影响最大。LPL基因座的X447等位基因在亚洲人群中很常见，且与动脉粥样硬化性较低的血脂谱相关。与APOE基因型、吸烟和饮酒的相互作用强化了在相关人群背景下研究此类基因关联的重要性。
