Bains G S, Dhake G S
Molecular Biology & Agriculture Division, Bhabha Atomic Research Centre, Trombay, Bombay, India.
Indian J Exp Biol. 1992 Jan;30(1):1-4.
Cyclophosphamide is a potent immunosuppressive agent and is being widely used in organ transplantation. The effects of this anti-rejection drug on lymphoid organs are poorly understood. Newborn Swiss mice injected with various doses of cyclophosphamide suffered from wasting disease at 4 weeks post treatment. The incidence of wasting disease was dose dependent. Haematological picture of the wasting animals revealed leukocytosis of variable degree. Lymphocyte/granulocyte ratio was not inhibited. The cyclophosphamide treatment caused shrinkage of lymphoid organs. Bone marrow showed degeneration of haematopoietic cells. The failure to sustain lymphopoiesis by the potential lymphoid sites following cyclophosphamide treatment and the associated immunological insufficiency resulted in the fatal wasting disease.
环磷酰胺是一种强效免疫抑制剂，在器官移植中被广泛应用。这种抗排斥药物对淋巴器官的影响尚不清楚。给新生瑞士小鼠注射不同剂量的环磷酰胺后，在治疗后4周出现消瘦病。消瘦病的发生率呈剂量依赖性。消瘦动物的血液学检查显示有不同程度的白细胞增多。淋巴细胞/粒细胞比值未受抑制。环磷酰胺治疗导致淋巴器官萎缩。骨髓显示造血细胞变性。环磷酰胺治疗后潜在的淋巴组织部位无法维持淋巴细胞生成以及相关的免疫功能不全导致了致命的消瘦病。
