Coimbra Maria, Rohrich Rod J, Chao James, Brown Spencer A
University of Texas Southwestern Medical Center, Dallas, 75390, USA.
Plast Reconstr Surg. 2004 Apr 15;113(5):1438-43; discussion 1444. doi: 10.1097/01.prs.0000113026.94292.0b.
Aged skin is characterized by rhytides but also by epidermal and dermal atrophy, rough skin texture, irregular pigmentation, telangiectasias, and laxity. Microdermabrasion is an office-based mechanical resurfacing technique alternative to traditional dermabrasion. It has been used in Europe since 1992 with great acceptance. The purpose of this study was to evaluate and quantify the degree of visible improvement in photodamaged skin and fine rhytides following a series of microdermabrasion treatments. A single operator treated 20 patients with varying degrees of photodamage and rhytides with a series of eight microdermabrasion treatments at 1-week intervals; 17 subjects completed the entire study protocol. Standardized photographic documentation was performed before and after each treatment, and a survey questionnaire was completed by each subject. Punch biopsy specimens (3 mm) were collected on treated and matched nontreated control sites and evaluated for histological characteristics. Preprocedure and postprocedure photographs were rated on a 5-point scale by independent blinded observers. A total of 30 blinded observers (16 plastic surgeons and 14 laypersons) rated all photographs. The results showed that all observers rated a significant improvement of hyperchromic discoloration (p = 0.004), while only nonmedical observers observed improvement in fine rhytides. All patients were very satisfied with the results. Common side effects were mild to moderate discomfort occurring on bony areas during the treatment and an itching and tingling sensation for 2 days after treatment. No infections or scars were observed postoperatively. The average epidermal thickness in the untreated samples was 103 +/- 23 microM (mean +/- SD) before treatment compared with 148 +/- 41 microM after treatment (p < 0.001). Histologic analysis of the matched punch biopsy specimens showed an increase in organized collagen in treated versus nontreated sites. Treatment of aged skin using a series of microdermabrasion treatments is an effective, noninvasive method of skin rejuvenation with minimal risk and patient downtime. It is safe and improves skin quality by minimizing certain hyperchromic pigmentations.
老化皮肤的特征不仅在于皱纹，还包括表皮和真皮萎缩、皮肤质地粗糙、色素沉着不均、毛细血管扩张以及皮肤松弛。微晶磨皮术是一种在诊所进行的机械磨皮技术，是传统磨皮术的替代方法。自1992年以来，它在欧洲得到了广泛应用并深受欢迎。本研究的目的是评估和量化经过一系列微晶磨皮治疗后，光损伤皮肤和细纹的可见改善程度。由一名操作人员对20名有不同程度光损伤和皱纹的患者进行了一系列共8次微晶磨皮治疗，治疗间隔为1周；17名受试者完成了整个研究方案。在每次治疗前后进行了标准化的照相记录，并且每位受试者都完成了一份调查问卷。在治疗部位和匹配的未治疗对照部位采集了3毫米的钻孔活检标本，并对其组织学特征进行了评估。由独立的不知情观察者对术前和术后照片进行5分制评分。共有30名不知情观察者（16名整形外科医生和14名非专业人员）对所有照片进行了评分。结果显示，所有观察者都评定色素沉着过度有显著改善（p = 0.004），而只有非医学观察者观察到细纹有改善。所有患者对结果都非常满意。常见的副作用是治疗期间在骨区出现轻度至中度不适，以及治疗后2天出现瘙痒和刺痛感。术后未观察到感染或瘢痕。未治疗样本在治疗前的平均表皮厚度为103±23微米（平均值±标准差），治疗后为148±41微米（p < 0.001）。对匹配的钻孔活检标本进行的组织学分析显示，治疗部位与未治疗部位相比，有序排列的胶原蛋白有所增加。使用一系列微晶磨皮治疗老化皮肤是一种有效、无创的皮肤年轻化方法，风险极小且患者恢复时间短。它安全且通过减少某些色素沉着过度改善了皮肤质量。
