Makino Elizabeth T, Huang Priscilla C, Emmerich Tanja, Jiang Lily I, Mehta Rahul C
SkinMedica - Allergan Aesthetics, an AbbVie Company, Irvine, CA, USA.
SGS Stephens Inc, Richardson, TX, USA.
Clin Cosmet Investig Dermatol. 2023 Apr 27;16:1123-1134. doi: 10.2147/CCID.S399846. eCollection 2023.
There is growing interest in combining topical treatments with aesthetic procedures to combat signs of aging skin. This study aimed to assess the efficacy and tolerability of a novel cosmetic serum containing 5 different forms of HA (HA DG) when used via a proprietary diamond-tip microdermabrasion procedure (DG) to treat skin dryness, fine lines/wrinkles, rough texture, and dullness.
In this open-label, single-center study, participants received HA DG as part of a biweekly DG procedure on the face and neck for 12 weeks. Study participants also applied another take-home HA serum to the face twice daily at home, along with a basic skincare regimen. The efficacy of the combined treatment was measured by clinical quantification of multiple skin appearance features, analysis of bioinstrumental measurements, and digital photography.
This study enrolled 27 participants, with an average age of 42.7 years and Fitzpatrick skin phototypes I-III (59.3%), IV (18.5%), and V-VI (22.2%), and 23 participants completed the study. The combined treatment had effects in fine lines/wrinkles, skin dryness, smoothness, radiance, firmness, and hydration 15 minutes post-DG. Furthermore, the significant improvements observed in dryness, fine lines/wrinkles, skin smoothness, and radiance were still visible 3 days after and maintained at week 12. Additionally, smoothing of coarse lines/wrinkles, improvement of skin tone evenness, hyperpigmentation, photodamage, and transepidermal water loss were observed at week 12. The treatment had a favorable tolerability profile and was perceived as efficacious and highly satisfactory.
This novel combined treatment delivered immediate and prolonged skin hydration and high participant satisfaction, proving it can be an excellent approach for skin rejuvenation.
将局部治疗与美容手术相结合以对抗皮肤老化迹象的兴趣日益浓厚。本研究旨在评估一种含有5种不同形式透明质酸（HA DG）的新型美容精华液，通过专利钻石微针磨皮程序（DG）用于治疗皮肤干燥、细纹/皱纹、粗糙质地和暗沉时的疗效和耐受性。
在这项开放标签、单中心研究中，参与者每两周接受一次HA DG，作为面部和颈部DG程序的一部分，为期12周。研究参与者在家中还每天两次在面部涂抹另一种带回家使用的透明质酸精华液，同时配合基本的护肤方案。通过对多种皮肤外观特征进行临床量化、生物仪器测量分析和数码摄影来衡量联合治疗的疗效。
本研究招募了27名参与者，平均年龄为42.7岁，Fitzpatrick皮肤光型为I - III型（59.3%）、IV型（18.5%）和V - VI型（22.2%），23名参与者完成了研究。联合治疗在DG后15分钟对细纹/皱纹、皮肤干燥、光滑度、光泽度、紧致度和水合作用有效果。此外，在DG后3天观察到的皮肤干燥、细纹/皱纹、皮肤光滑度和光泽度的显著改善在第12周仍可见且持续存在。另外，在第12周观察到粗纹/皱纹变平滑、肤色均匀度改善、色素沉着、光损伤和经表皮水分流失减少。该治疗具有良好的耐受性，被认为有效且高度令人满意。
这种新型联合治疗能立即并持久地为皮肤补水，且参与者满意度高，证明它可以成为一种出色的皮肤年轻化方法。
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